Literature DB >> 18567817

Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate.

Julie L Brunelle1, Jeffrey J Shaw, Elaine M Youngman, Rachel Green.   

Abstract

Peptide release on the ribosome is catalyzed by protein release factors (RFs) on recognition of stop codons positioned in the A site of the small ribosomal subunit. Here we show that the 2' OH of the peptidyl-tRNA substrate plays an essential role in catalysis of the peptide release reaction. These observations parallel earlier studies of the mechanism of the peptidyl transfer reaction and argue that related mechanisms are at the heart of catalysis for these reactions.

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Year:  2008        PMID： 18567817      PMCID： PMC2491474          DOI： 10.1261/rna.1057908

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  22 in total

1.  Stop codon recognition and interactions with peptide release factor RF3 of truncated and chimeric RF1 and RF2 from Escherichia coli.

Authors:  Liliana Mora; Andrei Zavialov; Måns Ehrenberg; Richard H Buckingham
Journal:  Mol Microbiol       Date:  2003-12       Impact factor: 3.501

2.  The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.

Authors:  Norbert Polacek; Maria J Gomez; Koichi Ito; Liqun Xiong; Yoshikazu Nakamura; Alexander Mankin
Journal:  Mol Cell       Date:  2003-01       Impact factor: 17.970

3.  Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.

Authors:  Hyundae D Cho; Adegboyega K Oyelere; Scott A Strobel; Alan M Weiner
Journal:  RNA       Date:  2003-08       Impact factor: 4.942

4.  The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation.

Authors:  Malte Beringer; Sarah Adio; Wolfgang Wintermeyer; Marina Rodnina
Journal:  RNA       Date:  2003-08       Impact factor: 4.942

5.  The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release.

Authors:  Elaine M Youngman; Julie L Brunelle; Anna B Kochaniak; Rachel Green
Journal:  Cell       Date:  2004-05-28       Impact factor: 41.582

6.  The ribosome as an entropy trap.

Authors:  Annette Sievers; Malte Beringer; Marina V Rodnina; Richard Wolfenden
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-12       Impact factor: 11.205

7.  Two distinct components of release factor function uncovered by nucleophile partitioning analysis.

Authors:  Jeffrey J Shaw; Rachel Green
Journal:  Mol Cell       Date:  2007-11-09       Impact factor: 17.970

8.  The behaviour of acetylphenylalanyl soluble ribonucleic acid in polyphenylalanine synthesis.

Authors:  A L Haenni; F Chapeville
Journal:  Biochim Biophys Acta       Date:  1966-01-18

9.  Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition.

Authors:  A Seit-Nebi; L Frolova; J Justesen; L Kisselev
Journal:  Nucleic Acids Res       Date:  2001-10-01       Impact factor: 16.971

10.  Mononucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2'-OH to activity.

Authors:  Silke Dorner; Claudia Panuschka; Walther Schmid; Andrea Barta
Journal:  Nucleic Acids Res       Date:  2003-11-15       Impact factor: 16.971
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  21 in total

1.  Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release.

Authors:  Hong Jin; Ann C Kelley; David Loakes; V Ramakrishnan
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

2.  Recognition of the amber UAG stop codon by release factor RF1.

Authors:  Andrei Korostelev; Jianyu Zhu; Haruichi Asahara; Harry F Noller
Journal:  EMBO J       Date:  2010-06-29       Impact factor: 11.598

3.  Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA.

Authors:  Miljan Simonović; Thomas A Steitz
Journal:  RNA       Date:  2008-09-25       Impact factor: 4.942

4.  The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC.

Authors:  Hani S Zaher; Jeffrey J Shaw; Scott A Strobel; Rachel Green
Journal:  EMBO J       Date:  2011-05-06       Impact factor: 11.598

Review 5.  Structural aspects of translation termination on the ribosome.

Authors:  Andrei A Korostelev
Journal:  RNA       Date:  2011-06-23       Impact factor: 4.942

6.  Different substrate-dependent transition states in the active site of the ribosome.

Authors:  Stephan Kuhlenkoetter; Wolfgang Wintermeyer; Marina V Rodnina
Journal:  Nature       Date:  2011-07-31       Impact factor: 49.962

7.  Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone.

Authors:  Hannah E Keedy; Erica N Thomas; Hani S Zaher
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-02       Impact factor: 11.205

8.  Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects.

Authors:  David A Hiller; Minghong Zhong; Vipender Singh; Scott A Strobel
Journal:  Biochemistry       Date:  2010-05-11       Impact factor: 3.162

9.  Quality control by the ribosome following peptide bond formation.

Authors:  Hani S Zaher; Rachel Green
Journal:  Nature       Date:  2008-12-17       Impact factor: 49.962

10.  A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue.

Authors:  Jeffrey J Shaw; Stefan Trobro; Shan L He; Johan Åqvist; Rachel Green
Journal:  Chem Biol       Date:  2012-08-24
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