Literature DB >> 18567659

AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli.

Hidetada Hirakawa1, Asuka Takumi-Kobayashi, Ulrike Theisen, Takahiro Hirata, Kunihiko Nishino, Akihito Yamaguchi.   

Abstract

The acrS regulatory gene is located upstream of the acrEF multidrug efflux system genes. However, the roles of AcrS in regulation of drug efflux pumps have not been clearly understood. Here we show that AcrS represses other multidrug efflux genes, acrAB, which encode a major efflux system in Escherichia coli.

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Year:  2008        PMID： 18567659      PMCID： PMC2546796          DOI： 10.1128/JB.00190-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

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Authors:  H Nikaido
Journal:  Curr Opin Microbiol       Date:  1998-10       Impact factor: 7.934

Review 2.  Efflux-mediated multiresistance in Gram-negative bacteria.

Authors:  K Poole
Journal:  Clin Microbiol Infect       Date:  2004-01       Impact factor: 8.067

3.  Position and density effects on repression by stationary and mobile DNA-binding proteins.

Authors:  S J Elledge; R W Davis
Journal:  Genes Dev       Date:  1989-02       Impact factor: 11.361

4.  Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli.

Authors:  R G Martin; K W Jair; R E Wolf; J L Rosner
Journal:  J Bacteriol       Date:  1996-04       Impact factor: 3.490

5.  Transcriptional activation of promoters of the superoxide and multiple antibiotic resistance regulons by Rob, a binding protein of the Escherichia coli origin of chromosomal replication.

Authors:  K W Jair; X Yu; K Skarstad; B Thöny; N Fujita; A Ishihama; R E Wolf
Journal:  J Bacteriol       Date:  1996-05       Impact factor: 3.490

6.  Regulation of the permeability of the gonococcal cell envelope by the mtr system.

Authors:  W Pan; B G Spratt
Journal:  Mol Microbiol       Date:  1994-02       Impact factor: 3.501

7.  Efflux pumps and drug resistance in gram-negative bacteria.

Authors:  D Ma; D N Cook; J E Hearst; H Nikaido
Journal:  Trends Microbiol       Date:  1994-12       Impact factor: 17.079

8.  Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein.

Authors:  Emiko Y Rosenberg; Dan Bertenthal; Matthew L Nilles; Kevin P Bertrand; Hiroshi Nikaido
Journal:  Mol Microbiol       Date:  2003-06       Impact factor: 3.501

9.  Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization.

Authors:  A J Link; D Phillips; G M Church
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

10.  Ambidextrous transcriptional activation by SoxS: requirement for the C-terminal domain of the RNA polymerase alpha subunit in a subset of Escherichia coli superoxide-inducible genes.

Authors:  K W Jair; W P Fawcett; N Fujita; A Ishihama; R E Wolf
Journal:  Mol Microbiol       Date:  1996-01       Impact factor: 3.501
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  24 in total

1.  AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters.

Authors:  Katsuhiko Hayashi; Ryosuke Nakashima; Keisuke Sakurai; Kimie Kitagawa; Seiji Yamasaki; Kunihiko Nishino; Akihito Yamaguchi
Journal:  J Bacteriol       Date:  2015-11-02       Impact factor: 3.490

Review 2.  The TetR family of regulators.

Authors:  Leslie Cuthbertson; Justin R Nodwell
Journal:  Microbiol Mol Biol Rev       Date:  2013-09       Impact factor: 11.056

Review 3.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

4.  Effect of NlpE overproduction on multidrug resistance in Escherichia coli.

Authors:  Kunihiko Nishino; Seiji Yamasaki; Mitsuko Hayashi-Nishino; Akihito Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  2010-03-08       Impact factor: 5.191

Review 5.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

6.  Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648.

Authors:  Toyotaka Sato; Yuuki Suzuki; Tsukasa Shiraishi; Hiroyuki Honda; Masaaki Shinagawa; Soh Yamamoto; Noriko Ogasawara; Hiroki Takahashi; Satoshi Takahashi; Yutaka Tamura; Shin-Ichi Yokota
Journal:  Antimicrob Agents Chemother       Date:  2017-01-24       Impact factor: 5.191

7.  Importance of Real-Time Assays To Distinguish Multidrug Efflux Pump-Inhibiting and Outer Membrane-Destabilizing Activities in Escherichia coli.

Authors:  Rajeev Misra; Keith D Morrison; Hyun Jae Cho; Thanh Khuu
Journal:  J Bacteriol       Date:  2015-05-11       Impact factor: 3.490

8.  Limited Multidrug Resistance Efflux Pump Overexpression among Multidrug-Resistant Escherichia coli Strains of ST131.

Authors:  Johannes Camp; Sabine Schuster; Martina Vavra; Tobias Schweigger; John W A Rossen; Sandra Reuter; Winfried V Kern
Journal:  Antimicrob Agents Chemother       Date:  2021-03-18       Impact factor: 5.191

9.  Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG.

Authors:  Anna Fàbrega; Robert G Martin; Judah L Rosner; M Mar Tavio; Jordi Vila
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

10.  Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters.

Authors:  Ashley Parker; Susan Gottesman
Journal:  J Bacteriol       Date:  2016-01-25       Impact factor: 3.490
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