Barbara K Ballmer-Weber1, Stefan Vieths. 1. Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. barbara.ballmer@usz.ch
Abstract
PURPOSE OF REVIEW: The purpose of this paper is to review and discuss studies on soy allergy. RECENT FINDINGS: In Central Europe soy is a clinically relevant birch pollen-related allergenic food. Crossreaction is mediated by a Bet v 1 homologous protein, Gly m 4. Additionally, birch pollen allergic patients might acquire through Bet v 1 sensitization allergies to mungbean or peanut, in which Vig r 1 and Ara h 8 are the main cross-reactive allergens. Threshold doses in soy allergic individuals range from 10 mg to 50 g of soy and are more than one order of magnitude higher than in peanut allergy. No evidence was found for increased allergenicity of genetically modified soybeans. SUMMARY: In Europe, both primary and pollen-related food allergy exist. The diagnosis of legume allergy in birch pollen-sensitized patients should not be excluded on a negative IgE testing to legume extracts. Bet v 1 related allergens are often underrepresented in extracts. Gly m 4 from soy and Ara h 8 from peanut are nowadays commercially available and are recommended in birch pollen allergic patients with suspicion of soy or peanut allergy, but negative extract-based diagnostic tests to screen for IgE specific to these recombinant allergens.
PURPOSE OF REVIEW: The purpose of this paper is to review and discuss studies on soy allergy. RECENT FINDINGS: In Central Europe soy is a clinically relevant birch pollen-related allergenic food. Crossreaction is mediated by a Bet v 1 homologous protein, Gly m 4. Additionally, birch pollen allergicpatients might acquire through Bet v 1 sensitization allergies to mungbean or peanut, in which Vig r 1 and Ara h 8 are the main cross-reactive allergens. Threshold doses in soy allergic individuals range from 10 mg to 50 g of soy and are more than one order of magnitude higher than in peanutallergy. No evidence was found for increased allergenicity of genetically modified soybeans. SUMMARY: In Europe, both primary and pollen-related food allergy exist. The diagnosis of legume allergy in birch pollen-sensitized patients should not be excluded on a negative IgE testing to legume extracts. Bet v 1 related allergens are often underrepresented in extracts. Gly m 4 from soy and Ara h 8 from peanut are nowadays commercially available and are recommended in birch pollen allergicpatients with suspicion of soy or peanutallergy, but negative extract-based diagnostic tests to screen for IgE specific to these recombinant allergens.
Authors: Pedro Diaz Vivancos; Simon P Driscoll; Christopher A Bulman; Liu Ying; Kaveh Emami; Achim Treumann; Caroline Mauve; Graham Noctor; Christine H Foyer Journal: Plant Physiol Date: 2011-07-14 Impact factor: 8.340
Authors: Eva Elisabeth Guhsl; Gerlinde Hofstetter; Wolfgang Hemmer; Christof Ebner; Stefan Vieths; Lothar Vogel; Heimo Breiteneder; Christian Radauer Journal: Mol Nutr Food Res Date: 2013-09-01 Impact factor: 5.914
Authors: Margitta Worm; Imke Reese; Barbara Ballmer-Weber; Kirsten Beyer; Stephan C Bischoff; Martin Classen; Peter J Fischer; Thomas Fuchs; Isidor Huttegger; Uta Jappe; Ludger Klimek; Berthold Koletzko; Lars Lange; Ute Lepp; Vera Mahler; Bodo Niggemann; Ute Rabe; Martin Raithel; Joachim Saloga; Christiane Schäfer; Sabine Schnadt; Jens Schreiber; Zsolt Szépfalusi; Regina Treudler; Martin Wagenmann; Bernhard Watzl; Thomas Werfel; Torsten Zuberbier; Jörg Kleine-Tebbe Journal: Allergo J Int Date: 2015-11-07