OBJECTIVE: To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function. DESIGN: Prospective, before-after trial. SETTING: Outpatient clinic of a university clinic for otorhinolaryngology. PATIENTS: A total of 20 patients with olfactory loss participated in the study. The duration of olfactory deficits ranged from 3 months to 6 years. MAIN OUTCOME MEASURES: Olfactory function was assessed for phenyl ethyl alcohol odor threshold, odor discrimination, and odor identification. Olfactory bulb volume was determined using magnetic resonance imaging. RESULTS: In initially hyposmic patients (n = 13), changes in OB volume were found to correlate with odor threshold changes (r = 0.82; P = .001); no such correlation was found for odor discrimination or odor identification. CONCLUSION: As demonstrated in a longitudinal study for the first time to our knowledge, the human OB is a highly plastic structure that responds to individual changes in olfactory status.
OBJECTIVE: To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function. DESIGN: Prospective, before-after trial. SETTING:Outpatient clinic of a university clinic for otorhinolaryngology. PATIENTS: A total of 20 patients with olfactory loss participated in the study. The duration of olfactory deficits ranged from 3 months to 6 years. MAIN OUTCOME MEASURES: Olfactory function was assessed for phenyl ethyl alcohol odor threshold, odor discrimination, and odor identification. Olfactory bulb volume was determined using magnetic resonance imaging. RESULTS: In initially hyposmic patients (n = 13), changes in OB volume were found to correlate with odor threshold changes (r = 0.82; P = .001); no such correlation was found for odor discrimination or odor identification. CONCLUSION: As demonstrated in a longitudinal study for the first time to our knowledge, the humanOB is a highly plastic structure that responds to individual changes in olfactory status.
Authors: M K Lee; J H Lee; J H Kim; H Kim; L Joo; M Kim; S J Cho; C H Suh; S R Chung; Y J Choi; J H Baek Journal: AJNR Am J Neuroradiol Date: 2020-08-06 Impact factor: 3.825
Authors: Sarah E Latchney; Phillip D Rivera; Xiao W Mao; Virginia L Ferguson; Ted A Bateman; Louis S Stodieck; Gregory A Nelson; Amelia J Eisch Journal: J Appl Physiol (1985) Date: 2014-04-17