Literature DB >> 18558745

C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.

Nobuwa Aoki1, Mai Muko, Emi Ohta, Shinji Ohta.   

Abstract

An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoangelol B (4). The structures of 1-3 were determined on the basis of the analysis of their spectroscopic data. Compounds 1-4 exhibited potent superoxide-scavenging activity.

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Year:  2008        PMID： 18558745     DOI： 10.1021/np800187f

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

Review 1.  The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.

Authors:  Vivek R Yadav; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Journal:  Int Immunopharmacol       Date:  2010-12-22       Impact factor: 4.932

2.  QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity.

Authors:  Marcelo N Gomes; Rodolpho C Braga; Edyta M Grzelak; Bruno J Neves; Eugene Muratov; Rui Ma; Larry L Klein; Sanghyun Cho; Guilherme R Oliveira; Scott G Franzblau; Carolina Horta Andrade
Journal:  Eur J Med Chem       Date:  2017-05-10       Impact factor: 6.514

3.  Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum.

Authors:  Marcelo N Gomes; Laura M Alcântara; Bruno J Neves; Cleber C Melo-Filho; Lucio H Freitas-Junior; Carolina B Moraes; Rui Ma; Scott G Franzblau; Eugene Muratov; Carolina Horta Andrade
Journal:  Bioorg Med Chem Lett       Date:  2017-04-04       Impact factor: 2.823

4.  Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells.

Authors:  Yoon-Hee Choi; Hyun Sook Lee; Cha-Kwon Chung; Eun Ji Kim; Il-Jun Kang
Journal:  Nutr Res Pract       Date:  2017-03-10       Impact factor: 1.926

Review 5.  Chalcone Derivatives: Promising Starting Points for Drug Design.

Authors:  Marcelo N Gomes; Eugene N Muratov; Maristela Pereira; Josana C Peixoto; Lucimar P Rosseto; Pedro V L Cravo; Carolina H Andrade; Bruno J Neves
Journal:  Molecules       Date:  2017-07-25       Impact factor: 4.411

6.  Characterizing Tyrosinase Modulators from the Roots of Angelica keiskei Using Tyrosinase Inhibition Assay and UPLC-MS/MS as the Combinatorial Novel Approach.

Authors:  Jia-Hao Lee; Hui-Ching Mei; I-Chih Kuo; Tzong-Huei Lee; Yu-Hsin Chen; Ching-Kuo Lee
Journal:  Molecules       Date:  2019-09-10       Impact factor: 4.411

7.  Effects of Microbial Transformation on the Biological Activities of Prenylated Chalcones from Angelica keiskei.

Authors:  Yina Xiao; Ik-Soo Lee
Journal:  Foods       Date:  2022-02-14

8.  Biocatalytic access to diverse prenylflavonoids by combining a regiospecific C-prenyltransferase and a stereospecific chalcone isomerase.

Authors:  Jianhua Li; Ridao Chen; Ruishan Wang; Xiao Liu; Kebo Xie; Dawei Chen; Jungui Dai
Journal:  Acta Pharm Sin B       Date:  2018-03-05       Impact factor: 11.413

Review 9.  Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities.

Authors:  Yun-Seo Kil; Sally T Pham; Eun Kyoung Seo; Mahtab Jafari
Journal:  Arch Pharm Res       Date:  2017-04-24       Impact factor: 4.946

10.  Design and development of innovative microparticulate/nanoparticulate inhalable dry powders of a novel synthetic trifluorinated chalcone derivative and Nrf2 agonist.

Authors:  Priya Muralidharan; Brielle Jones; Graham Allaway; Shyam S Biswal; Heidi M Mansour
Journal:  Sci Rep       Date:  2020-11-13       Impact factor: 4.996
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