| Literature DB >> 18558670 |
Darren K MacFarland1, Kenneth L Walker, Robert P Lenk, Stephen R Wilson, Krishan Kumar, Christopher L Kepley, Joel R Garbow.
Abstract
Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.Entities:
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Year: 2008 PMID： 18558670 PMCID： PMC2630425 DOI： 10.1021/jm800521j
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446