OBJECTIVES: To follow a population of preschool children with and without parent reported wheeze over a period of 6-11 years to determine prognosis and its important predictive factors. DESIGN: Longitudinal series of five postal surveys based on the international study of asthma and allergies in childhood questionnaire carried out between 1993 and 2004. SETTING: Two general practice populations, south Manchester. PARTICIPANTS: 628 children aged less than 5 years at recruitment and those with at least six years' follow-up data. MAIN OUTCOME MEASURES: Parent completed questionnaire data for respiratory symptoms and associated features. RESULTS: Of 628 children included in the study, 201 (32%) had parent reported wheeze at the first observation (baseline), of whom 27% also reported the symptom on the second occasion (persistent asthma). The only important baseline predictors of persistent asthma were exercise induced wheeze (odds ratio 3.94, 95% confidence interval 1.72 to 9.00) and a history of atopic disorders (4.44, 1.94 to 10.13). The presence of both predictors indicated a likelihood of 53.2% of developing asthma; if only one feature was present this decreased to 17.2%, whereas if neither was present the likelihood was 10.9%. Family history of asthma was not predictive of persistent asthma among children with preschool wheeze. CONCLUSION: Using two simple predictive factors (baseline parent reported exercise induced wheeze and a history of atopic disorders), it is possible to estimate the likelihood of future asthma in children presenting with preschool wheeze. The absence of baseline exercise induced wheeze and a history of atopic disorders reduces the likelihood of subsequent asthma by a factor of five.
OBJECTIVES: To follow a population of preschool children with and without parent reported wheeze over a period of 6-11 years to determine prognosis and its important predictive factors. DESIGN: Longitudinal series of five postal surveys based on the international study of asthma and allergies in childhood questionnaire carried out between 1993 and 2004. SETTING: Two general practice populations, south Manchester. PARTICIPANTS: 628 children aged less than 5 years at recruitment and those with at least six years' follow-up data. MAIN OUTCOME MEASURES: Parent completed questionnaire data for respiratory symptoms and associated features. RESULTS: Of 628 children included in the study, 201 (32%) had parent reported wheeze at the first observation (baseline), of whom 27% also reported the symptom on the second occasion (persistent asthma). The only important baseline predictors of persistent asthma were exercise induced wheeze (odds ratio 3.94, 95% confidence interval 1.72 to 9.00) and a history of atopic disorders (4.44, 1.94 to 10.13). The presence of both predictors indicated a likelihood of 53.2% of developing asthma; if only one feature was present this decreased to 17.2%, whereas if neither was present the likelihood was 10.9%. Family history of asthma was not predictive of persistent asthma among children with preschool wheeze. CONCLUSION: Using two simple predictive factors (baseline parent reported exercise induced wheeze and a history of atopic disorders), it is possible to estimate the likelihood of future asthma in children presenting with preschool wheeze. The absence of baseline exercise induced wheeze and a history of atopic disorders reduces the likelihood of subsequent asthma by a factor of five.
Authors: Helen L Rhodes; Peter Thomas; Richard Sporik; Stephen T Holgate; Jeremy J Cogswell Journal: Am J Respir Crit Care Med Date: 2002-01-15 Impact factor: 21.405
Authors: Wayne J Morgan; Debra A Stern; Duane L Sherrill; Stefano Guerra; Catharine J Holberg; Theresa W Guilbert; Lynn M Taussig; Anne L Wright; Fernando D Martinez Journal: Am J Respir Crit Care Med Date: 2005-08-18 Impact factor: 21.405
Authors: L García-Marcos; M Morales Suárez-Varela; I Miner Canflanca; J Batlles Garrido; A Blanco Quirós; A López-Silvarrey Varela; G García Hernández; F Guillén-Grima; C González Díaz; I Huerta González; A Arnedo Pena; R Busquets Monge Journal: Int Arch Allergy Immunol Date: 2005-06-20 Impact factor: 2.749
Authors: Mustafa Osman; Nara Tagiyeva; Heather J Wassall; Titus K Ninan; Anne M Devenny; Geraldine McNeill; Peter J Helms; George Russell Journal: Pediatr Pulmonol Date: 2007-01
Authors: Peter I Frank; Paul D Wicks; Michelle L Hazell; Mary F Linehan; Sybil Hirsch; Philip C Hannaford; Timothy L Frank Journal: Br J Gen Pract Date: 2005-08 Impact factor: 5.386
Authors: S Chinn; D Jarvis; P Burney; C Luczynska; U Ackermann-Liebrich; J M Antó; I Cerveri; R De Marco; T Gislason; J Heinrich; C Janson; N Künzli; B Leynaert; F Neukirch; J Schouten; J Sunyer; C Svanes; P Vermeire; M Wjst Journal: Thorax Date: 2004-08 Impact factor: 9.139
Authors: Teal S Hallstrand; William A Altemeier; Moira L Aitken; William R Henderson Journal: Immunol Allergy Clin North Am Date: 2013-03-29 Impact factor: 3.479
Authors: John P Capitanio; Lisa A Miller; Edward S Schelegle; Sally P Mendoza; William A Mason; Dallas M Hyde Journal: Psychosom Med Date: 2011-05-02 Impact factor: 4.312
Authors: Teal S Hallstrand; Ying Lai; William R Henderson; William A Altemeier; Michael H Gelb Journal: Pulm Pharmacol Ther Date: 2012-12 Impact factor: 3.410