Literature DB >> 1855583

DNA methylation and chromatin structure.

J Lewis1, A Bird.   

Abstract

Studies of the whole genome by molecular and cytogenetic methods have implicated DNA methylation in the formation of 'inactive chromatin'. This has been confirmed by analysis of specific endogenous sequences, and has been mimicked by introducing methylated and non-methylated sequences into cells. As well as affecting chromatin structure. DNA methylation also represses transcription. A protein (MeCP) which binds specifically to methylated DNA has been identified. The properties of MeCP could account for the effects of DNA methylation on both chromatin and transcription.

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Year:  1991        PMID： 1855583     DOI： 10.1016/0014-5793(91)80795-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  45 in total

1.  Expression of ZmMET1, a gene encoding a DNA methyltransferase from maize, is associated not only with DNA replication in actively proliferating cells, but also with altered DNA methylation status in cold-stressed quiescent cells.

Authors:  N Steward; T Kusano; H Sano
Journal:  Nucleic Acids Res       Date:  2000-09-01       Impact factor: 16.971

2.  Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA.

Authors:  A Eyre-Walker
Journal:  Genetics       Date:  1999-06       Impact factor: 4.562

3.  De novo cytosine methylation in the differentiating macronucleus of the stichotrichous ciliate Stylonychia lemnae.

Authors:  Stefan Juranek; Hans-Joachim Wieden; Hans J Lipps
Journal:  Nucleic Acids Res       Date:  2003-03-01       Impact factor: 16.971

4.  Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.

Authors:  A Levine; G L Cantoni; A Razin
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

5.  Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.

Authors:  R R Meehan; J D Lewis; A P Bird
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

6.  Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis.

Authors:  Chandrika J Piyathilake; Walter C Bell; Jennifer Jones; Olga L Henao; Douglas C Heimburger; Alain Niveleau; William E Grizzle
Journal:  Head Neck       Date:  2005-12       Impact factor: 3.147

7.  Methylation of B-hordein genes in barley endosperm is inversely correlated with gene activity and affected by the regulatory gene Lys3.

Authors:  M B Sørensen
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

8.  Purification and characterization of the MspI DNA methyltransferase cloned and overexpressed in E. coli.

Authors:  A K Dubey; B Mollet; R J Roberts
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

9.  Tissue culture-induced DNA methylation polymorphisms in repetitive DNA of tomato calli and regenerated plants.

Authors:  M J Smulders; W Rus-Kortekaas; B Vosman
Journal:  Theor Appl Genet       Date:  1995-12       Impact factor: 5.699

10.  Methylation of the regulatory region of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene leads to its transcriptional inactivation.

Authors:  J Ayté; G Gil-Gómez; F G Hegardt
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857
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