Literature DB >> 18554905

Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.

Edite Verissimo1, Neil Berry, Peter Gibbons, M Lurdes S Cristiano, Philip J Rosenthal, Jiri Gut, Stephen A Ward, Paul M O'Neill.   

Abstract

The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18554905     DOI： 10.1016/j.bmcl.2008.05.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  De novo design of 7-aminocoumarin derivatives as novel falcipain-3 inhibitors.

Authors:  Anand S Chintakrindi; Mushtaque S Shaikh; Evans C Coutinho
Journal:  J Mol Model       Date:  2011-07-23       Impact factor: 1.810

2.  Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow.

Authors:  Thommas M Musyoka; Aquillah M Kanzi; Kevin A Lobb; Özlem Tastan Bishop
Journal:  J Biomol Struct Dyn       Date:  2016-01-28

3.  Novel anti-plasmodial hits identified by virtual screening of the ZINC database.

Authors:  Grace Mugumbate; Ana S Newton; Philip J Rosenthal; Jiri Gut; Rui Moreira; Kelly Chibale; Rita C Guedes
Journal:  J Comput Aided Mol Des       Date:  2013-10-25       Impact factor: 3.686

4.  2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists.

Authors:  Claudia Vergelli; Igor A Schepetkin; Giovanna Ciciani; Agostino Cilibrizzi; Letizia Crocetti; Maria Paola Giovannoni; Gabriella Guerrini; Antonella Iacovone; Liliya N Kirpotina; Andrei I Khlebnikov; Richard D Ye; Mark T Quinn
Journal:  Bioorg Med Chem       Date:  2016-04-08       Impact factor: 3.641

5.  Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents.

Authors:  Parvin Kumar; Kulbir Kadyan; Meenakshi Duhan; Jayant Sindhu; Vineeta Singh; Baljeet Singh Saharan
Journal:  Chem Cent J       Date:  2017-11-14       Impact factor: 4.215

6.  Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives.

Authors:  Shynggys Sergazy; Zarina Shulgau; Aigerim Zhulikeyeva; Yerlan Ramankulov; Irina V Palamarchuk; Ivan V Kulakov
Journal:  Molecules       Date:  2022-08-23       Impact factor: 4.927

7.  Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid.

Authors:  Marie-Adrienne Dude; Ulrich Kaeppler; Monika Herb; Markus Schiller; Franziska Schulz; Birgit Vedder; Saskia Heppner; Gabriele Pradel; Jiri Gut; Philip J Rosenthal; Tanja Schirmeister; Matthias Leippe; Christoph Gelhaus
Journal:  Molecules       Date:  2008-12-23       Impact factor: 4.411

8.  Zinc (II)-Mediated Selective O-Benzylation of 2-Oxo-1,2-Dihydropyridines Systems.

Authors:  Qifan Zhou; Fangyu Du; Xinjie Liang; Wenqiang Liu; Ting Fang; Guoliang Chen
Journal:  Molecules       Date:  2018-07-20       Impact factor: 4.411
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.