Literature DB >> 18553926

Sinulaflexiolides A-K, cembrane-type diterpenoids from the chinese soft coral Sinularia flexibilis.

Ting Wen1, Yi Ding, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin.   

Abstract

A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A-K (1-11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 microM, respectively.

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Year:  2008        PMID： 18553926     DOI： 10.1021/np070640g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  A surprising mechanistic "switch" in Lewis acid activation: a bifunctional, asymmetric approach to alpha-hydroxy acid derivatives.

Authors:  Ciby J Abraham; Daniel H Paull; Tefsit Bekele; Michael T Scerba; Travis Dudding; Thomas Lectka
Journal:  J Am Chem Soc       Date:  2008-12-17       Impact factor: 15.419

2.  Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular.

Authors:  Jui-Hsin Su; Zhi-Hong Wen
Journal:  Mar Drugs       Date:  2011-05-27       Impact factor: 6.085

3.  Trends in the discovery of new marine natural products from invertebrates over the last two decades--where and what are we bioprospecting?

Authors:  Miguel Costa Leal; João Puga; João Serôdio; Newton C M Gomes; Ricardo Calado
Journal:  PLoS One       Date:  2012-01-20       Impact factor: 3.240

4.  NMR-based metabolomic analysis of spatial variation in soft corals.

Authors:  Qing He; Ruiqi Sun; Huijuan Liu; Zhufeng Geng; Dawei Chen; Yinping Li; Jiao Han; Wenhan Lin; Shushan Du; Zhiwei Deng
Journal:  Mar Drugs       Date:  2014-03-28       Impact factor: 5.118

5.  Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo.

Authors:  Takashi Kamada; Min-Cheol Kang; Chin-Soon Phan; Intan Irna Zanil; You-Jin Jeon; Charles S Vairappan
Journal:  Mar Drugs       Date:  2018-03-21       Impact factor: 5.118

6.  New cembrane diterpenoids from a Hainan soft coral Sinularia sp.

Authors:  Bin Yang; Xuefeng Zhou; Hui Huang; Xian-Wen Yang; Juan Liu; Xiuping Lin; Xiubao Li; Yan Peng; Yonghong Liu
Journal:  Mar Drugs       Date:  2012-09-18       Impact factor: 6.085

7.  Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis.

Authors:  Ching-Chyuan Su; Bing-Sang Wong; Chuen Chin; Yu-Jen Wu; Jui-Hsin Su
Journal:  Int J Mol Sci       Date:  2013-02-21       Impact factor: 5.923

8.  Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis.

Authors:  Li-Chung Hu; Jui-Hsin Su; Michael Yen-Nan Chiang; Mei-Chin Lu; Tsong-Long Hwang; Yung-Husan Chen; Wan-Ping Hu; Nai-Cheng Lin; Wei-Hsien Wang; Lee-Shing Fang; Yueh-Hsiung Kuo; Ping-Jyun Sung
Journal:  Mar Drugs       Date:  2013-06-10       Impact factor: 5.118

9.  Immunomodulatory effect of marine cembrane-type diterpenoids on dendritic cells.

Authors:  Ching-Yen Lin; Mei-Chin Lu; Jui-Hsin Su; Ching-Liang Chu; David Shiuan; Ching-Feng Weng; Ping-Jyun Sung; Kao-Jean Huang
Journal:  Mar Drugs       Date:  2013-04-22       Impact factor: 5.118

10.  Cembrane derivatives from the soft corals, Sinularia gaweli and Sinularia flexibilis.

Authors:  Li-Chung Hu; Wei-Hsuan Yen; Jui-Hsin Su; Michael Yen-Nan Chiang; Zhi-Hong Wen; Wu-Fu Chen; Ting-Jang Lu; Yu-Wei Chang; Yung-Husan Chen; Wei-Hsien Wang; Yang-Chang Wu; Ping-Jyun Sung
Journal:  Mar Drugs       Date:  2013-06-17       Impact factor: 5.118
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