BACKGROUND: The success of dendritic cell (DC)-based immunotherapy in inducing cellular immunity against tumors is highly dependent on accurate delivery and trafficking of the DC to T-cell-rich areas of secondary lymphoid tissues. OBJECTIVE: To provide an overview of DC migration in vivo and how migration to peripheral lymph nodes might be improved to optimize DC therapy. METHODS: We focused on DC migration in preclinical models and human skin explants and on clinical vaccination trials studying migration of in vitro-generated DC. RESULTS/ CONCLUSIONS: DC migration requires an intricate interplay between the cell and its environment. To maximize migration for cellular therapy, it is important to optimize the generation of migratory DC as well as treatment strategies.
BACKGROUND: The success of dendritic cell (DC)-based immunotherapy in inducing cellular immunity against tumors is highly dependent on accurate delivery and trafficking of the DC to T-cell-rich areas of secondary lymphoid tissues. OBJECTIVE: To provide an overview of DC migration in vivo and how migration to peripheral lymph nodes might be improved to optimize DC therapy. METHODS: We focused on DC migration in preclinical models and human skin explants and on clinical vaccination trials studying migration of in vitro-generated DC. RESULTS/ CONCLUSIONS: DC migration requires an intricate interplay between the cell and its environment. To maximize migration for cellular therapy, it is important to optimize the generation of migratory DC as well as treatment strategies.
Authors: Sébastien Anguille; Evelien L J M Smits; Nathalie Cools; Herman Goossens; Zwi N Berneman; Vigor F I Van Tendeloo Journal: J Transl Med Date: 2009-12-18 Impact factor: 5.531
Authors: Rémi J Creusot; Shahriar S Yaghoubi; Pearl Chang; Justine Chia; Christopher H Contag; Sanjiv S Gambhir; C Garrison Fathman Journal: Blood Date: 2009-04-10 Impact factor: 22.113
Authors: Vivek Subbiah; Ravi Murthy; David S Hong; Robert M Prins; Chitra Hosing; Kyle Hendricks; Deepthi Kolli; Lori Noffsinger; Robert Brown; Mary McGuire; Siquing Fu; Sarina Piha-Paul; Aung Naing; Anthony P Conley; Robert S Benjamin; Indreshpal Kaur; Marnix L Bosch Journal: Clin Cancer Res Date: 2018-07-17 Impact factor: 12.531
Authors: Briana Jill Williams; Shilpa Bhatia; Lisa K Adams; Susan Boling; Jennifer L Carroll; Xiao-Lin Li; Donna L Rogers; Nikolay Korokhov; Imre Kovesdi; Alexander V Pereboev; David T Curiel; J Michael Mathis Journal: PLoS One Date: 2012-10-08 Impact factor: 3.240
Authors: Carlos Alfaro; Natalia Suárez; Ivan Martínez-Forero; Asís Palazón; Ana Rouzaut; Sarai Solano; Esperanza Feijoo; Alfonso Gúrpide; Elixabet Bolaños; Lorena Erro; Juan Dubrot; Sandra Hervás-Stubbs; Alvaro Gonzalez; Jose Luis Perez-Gracia; Ignacio Melero Journal: PLoS One Date: 2011-03-14 Impact factor: 3.240