| Literature DB >> 18547813 |
A C Serra1, M Pineiro, A M d'A Rocha Gonsalves, M Abrantes, M Laranjo, A C Santos, M F Botelho.
Abstract
Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC(50) of 113 nM over WiDr cells and 52nM over A375 cells.Entities:
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Year: 2008 PMID： 18547813 DOI： 10.1016/j.jphotobiol.2008.04.006
Source DB: PubMed Journal: J Photochem Photobiol B ISSN： 1011-1344 Impact factor: 6.252