Literature DB >> 18545912

Central mechanism of action of antimigraine prophylactic drugs.

Gerardo Casucci1, Veronica Villani, Fabio Frediani.   

Abstract

The pathogenesis of migraine is obscure. A hyperexcitable brain state has been postulated. Cortical spreading depression (CSD) is the most suggestive argument for the brain hyperexcitability. It has been showed that valproate, topiramate, amitriptyline and propranolol inhibit CSD in rats, which suggests that most preventative treatments of migraine act by normalising neuronal firing and increasing a genetically lowered and environmentally modified threshold for neuronal discharge. It has also been suggested that some antimigraine prophylactic drugs (i.e., amitriptyline, candesartan and magnesium) may act by restoring central nociceptive dysmodulation.

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Year:  2008        PMID： 18545912     DOI： 10.1007/s10072-008-0902-9

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  50 in total

1.  Lamotrigine versus placebo in the prophylaxis of migraine with and without aura.

Authors:  T J Steiner; L J Findley; A W Yuen
Journal:  Cephalalgia       Date:  1997-04       Impact factor: 6.292

2.  Topiramate for migraine prevention in adolescents: a pooled analysis of efficacy and safety.

Authors:  Paul Winner; Astrid Gendolla; Catherine Stayer; Steven Wang; Eric Yuen; Wendy P Battisti; Jeffrey S Nye
Journal:  Headache       Date:  2006 Nov-Dec       Impact factor: 5.887

3.  The concept of migraine as a state of central neuronal hyperexcitability.

Authors:  K M Welch; G D'Andrea; N Tepley; G Barkley; N M Ramadan
Journal:  Neurol Clin       Date:  1990-11       Impact factor: 3.806

Review 4.  Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society.

Authors:  D Lewis; S Ashwal; A Hershey; D Hirtz; M Yonker; S Silberstein
Journal:  Neurology       Date:  2004-12-28       Impact factor: 9.910

5.  Topiramate 100 mg/day in migraine prevention: a pooled analysis of double-blind randomised controlled trials.

Authors:  G Bussone; H-C Diener; J Pfeil; S Schwalen
Journal:  Int J Clin Pract       Date:  2005-08       Impact factor: 2.503

6.  Topiramate in the prophylaxis of pediatric migraine: a double-blind placebo-controlled trial.

Authors:  C V S Lakshmi; Pratibha Singhi; Prahbhjot Malhi; Munni Ray
Journal:  J Child Neurol       Date:  2007-07       Impact factor: 1.987

7.  Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy.

Authors:  J Overweg; C D Binnie; J W Meijer; H Meinardi; S T Nuijten; S Schmaltz; A Wauquier
Journal:  Epilepsia       Date:  1984-04       Impact factor: 5.864

8.  Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation.

Authors:  W van der Kamp; A Maassen VanDenBrink; M D Ferrari; J G van Dijk
Journal:  J Neurol Sci       Date:  1996-07       Impact factor: 3.181

9.  A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis.

Authors:  Frederick G Freitag; S D Collins; H A Carlson; J Goldstein; J Saper; S Silberstein; N Mathew; P K Winner; R Deaton; K Sommerville
Journal:  Neurology       Date:  2002-06-11       Impact factor: 9.910

10.  Lamotrigine inhibits depolarization-evoked Ca++ influx in dissociated amygdala neurons.

Authors:  S J Wang; J J Tsai; P W Gean
Journal:  Synapse       Date:  1998-08       Impact factor: 2.562
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  7 in total

Review 1.  Migraine and metabolism.

Authors:  G Casucci; V Villani; D Cologno; F D'Onofrio
Journal:  Neurol Sci       Date:  2012-05       Impact factor: 3.307

Review 2.  Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism.

Authors:  G D'Andrea; S Cevoli; D Colavito; A Leon
Journal:  Neurol Sci       Date:  2015-05       Impact factor: 3.307

Review 3.  Elusive amines: migraine depends on biochemical abnormalities.

Authors:  Giovanni D'Andrea; Antonina Gucciardi; Alberta Leon
Journal:  Neurol Sci       Date:  2022-07-16       Impact factor: 3.830

4.  Propranolol blocks cardiac and neuronal voltage-gated sodium channels.

Authors:  Dao W Wang; Akshitkumar M Mistry; Kristopher M Kahlig; Jennifer A Kearney; Jizhou Xiang; Alfred L George
Journal:  Front Pharmacol       Date:  2010-12-31       Impact factor: 5.810

5.  Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update.

Authors:  Sergio Carmona; Osvaldo Bruera
Journal:  Ther Clin Risk Manag       Date:  2009-08-20       Impact factor: 2.423

Review 6.  New drugs for migraine.

Authors:  Lars Jacob Stovner; Erling Tronvik; Knut Hagen
Journal:  J Headache Pain       Date:  2009-10-01       Impact factor: 7.277

7.  Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine.

Authors:  Adriana E Bulboacă; Sorana D Bolboacă; Ioana C Stănescu; Carmen A Sfrângeu; Angelo C Bulboacă
Journal:  Biomed Res Int       Date:  2017-10-24       Impact factor: 3.411
  7 in total

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