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Literature DB >> 18544015

Modulation of the inflammatory response for enhanced bone tissue regeneration.

Paschalia M Mountziaris¹, Antonios G Mikos.

Abstract

Proinflammatory cytokines are infamous for their catabolic effects on tissues and joints in both inflammatory diseases and following the implantation of biomedical devices. However, recent studies indicate that many of these same molecules are critical for triggering tissue regeneration following injury. This review will discuss the role of inflammatory signals in regulating bone regeneration and the impact of both immunomodulatory and antiinflammatory pharmacologic agents on fracture healing, to demonstrate the importance of incorporating rational control of inflammation into the design of tissue engineering strategies.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18544015 PMCID： PMC2962857 DOI： 10.1089/ten.teb.2008.0038

Source DB: PubMed Journal: Tissue Eng Part B Rev ISSN： 1937-3368 Impact factor: 6.389

72 in total

1. Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo.

Authors: Elizabeth L Hedberg; Henriette C Kroese-Deutman; Charles K Shih; Roger S Crowther; Darrell H Carney; Antonios G Mikos; John A Jansen
Journal: J Biomed Mater Res A Date: 2005-03-15 Impact factor: 4.396

2. Changes in bone mass and bone turnover following tibial shaft fracture.

Authors: S W Veitch; S C Findlay; A J Hamer; A Blumsohn; Richard Eastell; B M Ingle
Journal: Osteoporos Int Date: 2005-12-15 Impact factor: 4.507

Review 3. Cytokines regulating osteoclast formation and function.

Authors: Sun-Kyeong Lee; Joseph Lorenzo
Journal: Curr Opin Rheumatol Date: 2006-07 Impact factor: 5.006

Review 4. Cellular and molecular dynamics in the foreign body reaction.

Authors: Daniël T Luttikhuizen; Martin C Harmsen; Marja J A Van Luyn
Journal: Tissue Eng Date: 2006-07

5. How inflammation promotes regeneration.

Authors: Marie T Filbin
Journal: Nat Neurosci Date: 2006-06 Impact factor: 24.884

6. Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair.

Authors: Charles H Rundle; Hali Wang; Hongrun Yu; Robert B Chadwick; Emile I Davis; Jon E Wergedal; K-H William Lau; Subburaman Mohan; James T Ryaby; David J Baylink
Journal: Bone Date: 2006-04 Impact factor: 4.398

Review 7. Drugs and fracture repair.

Authors: Per Aspenberg
Journal: Acta Orthop Date: 2005-12 Impact factor: 3.717

8. Biochemical markers of bone turnover are influenced by recently sustained fracture.

Authors: Karl J Obrant; Kaisa K Ivaska; Paul Gerdhem; Sari L Alatalo; Kim Pettersson; H Kalervo Väänänen
Journal: Bone Date: 2005-03-31 Impact factor: 4.398

9. Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro.

Authors: Renate Balga; Antoinette Wetterwald; Jeannette Portenier; Silvia Dolder; Christoph Mueller; Willy Hofstetter
Journal: Bone Date: 2006-03-31 Impact factor: 4.398

Review 10. Current concepts of molecular aspects of bone healing.

Authors: Rozalia Dimitriou; Eleftherios Tsiridis; Peter V Giannoudis
Journal: Injury Date: 2005-08-15 Impact factor: 2.586

148 in total

1. Student Award for Outstanding Research Winner in the Ph.D. Category for the 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012: The interplay of bone-like extracellular matrix and TNF-α signaling on in vitro osteogenic differentiation of mesenchymal stem cells.

Authors: Paschalia M Mountziaris; Stephanie N Tzouanas; Antonios G Mikos
Journal: J Biomed Mater Res A Date: 2012-02-18 Impact factor: 4.396

Review 2. Strategies for controlled delivery of growth factors and cells for bone regeneration.

Authors: Tiffany N Vo; F Kurtis Kasper; Antonios G Mikos
Journal: Adv Drug Deliv Rev Date: 2012-02-04 Impact factor: 15.470

3. Overcoming endogenous constraints on neuronal regeneration.

Authors: Nassir Mokarram; Ravi V Bellamkonda
Journal: IEEE Trans Biomed Eng Date: 2010-12-30 Impact factor: 4.538

Review 4. Overview of biological mechanisms and applications of three murine models of bone repair: closed fracture with intramedullary fixation, distraction osteogenesis, and marrow ablation by reaming.

Authors: Beth Bragdon; Kyle Lybrand; Louis Gerstenfeld
Journal: Curr Protoc Mouse Biol Date: 2015-03-02

5. Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials.

Authors: Catarina R Almeida; Daniela P Vasconcelos; Raquel M Gonçalves; Mário A Barbosa
Journal: J R Soc Interface Date: 2011-07-13 Impact factor: 4.118

6. Effect of temporally patterned TNF-α delivery on in vitro osteogenic differentiation of mesenchymal stem cells cultured on biodegradable polymer scaffolds.

Authors: Paschalia M Mountziaris; E Dennis Lehman; Ioannis Mountziaris; David C Sing; F Kurtis Kasper; Antonios G Mikos
Journal: J Biomater Sci Polym Ed Date: 2013-06-08 Impact factor: 3.517