BACKGROUND: Childhood-onset mood disorders (COMD) include various serious, disabling psychiatric conditions that are heterogeneous in presentation and etiology. Because intermediate phenotypes may help to identify genetic contributors to COMD, we tested for an association between variants in the brain-derived neurotrophic factor (BDNF) gene and theta EEG asymmetry, both of which have been independently implicated in affective disorders. METHODS: Theta EEG asymmetry measures were calculated for a total of 191 individuals with COMD and 93 controls, who were also genotyped at seven BDNF single-nucleotide polymorphism (SNPs), two intergenic flanking SNPs, and one SNP in the lin-7 homolog C (Caenorhabditis elegans) (LIN7C) gene. RESULTS: Adjusting for sex and ethnicity in linear models of asymmetry scores at ten brain regions, significant genotype and genotype-by-ethnicity interactions were observed for marker Val66Met in two parietal (P3/4 and P7/8) regions in the depressed group only. CONCLUSIONS: Our results suggest that the functional Val66Met polymorphism affects theta EEG asymmetry in parietal brain regions specifically in individuals with COMD.
BACKGROUND: Childhood-onset mood disorders (COMD) include various serious, disabling psychiatric conditions that are heterogeneous in presentation and etiology. Because intermediate phenotypes may help to identify genetic contributors to COMD, we tested for an association between variants in the brain-derived neurotrophic factor (BDNF) gene and theta EEG asymmetry, both of which have been independently implicated in affective disorders. METHODS: Theta EEG asymmetry measures were calculated for a total of 191 individuals with COMD and 93 controls, who were also genotyped at seven BDNF single-nucleotide polymorphism (SNPs), two intergenic flanking SNPs, and one SNP in the lin-7 homolog C (Caenorhabditis elegans) (LIN7C) gene. RESULTS: Adjusting for sex and ethnicity in linear models of asymmetry scores at ten brain regions, significant genotype and genotype-by-ethnicity interactions were observed for marker Val66Met in two parietal (P3/4 and P7/8) regions in the depressed group only. CONCLUSIONS: Our results suggest that the functional Val66Met polymorphism affects theta EEG asymmetry in parietal brain regions specifically in individuals with COMD.
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