BACKGROUND: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. METHODS: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. RESULTS: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. CONCLUSIONS: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
BACKGROUND: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. METHODS: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. RESULTS: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. CONCLUSIONS: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
Authors: S Numata; S Ueno; J Iga; K Yamauchi; S Hongwei; S Kinouchi; S Shibuya-Tayoshi; S Tayoshi; H Aki; S Sumitani; M Itakura; T Ohmori Journal: J Neural Transm (Vienna) Date: 2006-08-08 Impact factor: 3.575
Authors: B G Schimmelmann; S Friedel; A Dempfle; A Warnke; K P Lesch; S Walitza; T J Renner; M Romanos; B Herpertz-Dahlmann; M Linder; H Schäfer; C Seitz; H Palmason; C Freitag; J Meyer; K Konrad; A Hinney; J Hebebrand Journal: J Neural Transm (Vienna) Date: 2007-01-15 Impact factor: 3.575
Authors: Natalie L Bulgin; John S Strauss; Nicole A King; Sajid A Shaikh; Charles J George; Nathan A Fox; Cathy L Barr; Maria Kovacs; James L Kennedy Journal: Neuromolecular Med Date: 2008-06-10 Impact factor: 3.843
Authors: Lixiang Liu; Tatiana Foroud; Xiaoling Xuei; Wade Berrettini; William Byerley; William Coryell; Rif El-Mallakh; Elliot S Gershon; John R Kelsoe; William B Lawson; Dean F MacKinnon; Melvin McInnis; Francis J McMahon; Dennis L Murphy; John Rice; William Scheftner; Peter P Zandi; Falk W Lohoff; Alexander B Niculescu; Eric T Meyer; Howard J Edenberg; John I Nurnberger Journal: Psychiatr Genet Date: 2008-12 Impact factor: 2.458