PURPOSE: To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES: To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated with total hip revision surgery were enrolled prospectively in this study. Six patients scheduled for primary hip arthroplasties were included as a control group. The study protocol consisted of three H2 15O and [18F]fluoride PET scans in each patient. RESULTS: Bone blood flow increased significantly compared to the preoperative state in patients treated for primary hip arthroplasty. In patients undergoing revision surgery, bone blood flow was twofold to threefold higher compared to the preoperative state, but did not reach significance. Bone metabolism in patients undergoing revision was threefold higher 2 weeks postoperatively compared to the primary hip group. We found a significant correlation between Ki and bone blood flow. CONCLUSIONS: Allogeneic bone grafts induce a higher rate of local periprosthetic bone formation compared to periprosthetic bone formation after a primary total hip placement. In vivo coupling between bone blood flow and bone metabolism suggests that bone metabolism in allogeneic bone grafts may partly rely on bone blood flow adaptations.
PURPOSE: To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES: To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated with total hip revision surgery were enrolled prospectively in this study. Six patients scheduled for primary hip arthroplasties were included as a control group. The study protocol consisted of three H2 15O and [18F]fluoride PET scans in each patient. RESULTS: Bone blood flow increased significantly compared to the preoperative state in patients treated for primary hip arthroplasty. In patients undergoing revision surgery, bone blood flow was twofold to threefold higher compared to the preoperative state, but did not reach significance. Bone metabolism in patients undergoing revision was threefold higher 2 weeks postoperatively compared to the primary hip group. We found a significant correlation between Ki and bone blood flow. CONCLUSIONS: Allogeneic bone grafts induce a higher rate of local periprosthetic bone formation compared to periprosthetic bone formation after a primary total hip placement. In vivo coupling between bone blood flow and bone metabolism suggests that bone metabolism in allogeneic bone grafts may partly rely on bone blood flow adaptations.
Authors: A A Lammertsma; V J Cunningham; M P Deiber; J D Heather; P M Bloomfield; J Nutt; R S Frackowiak; T Jones Journal: J Cereb Blood Flow Metab Date: 1990-09 Impact factor: 6.200
Authors: R A Hawkins; Y Choi; S C Huang; C K Hoh; M Dahlbom; C Schiepers; N Satyamurthy; J R Barrio; M E Phelps Journal: J Nucl Med Date: 1992-05 Impact factor: 10.057
Authors: B Willem Schreurs; J J Chris Arts; Nico Verdonschot; Pieter Buma; Tom J J H Slooff; Jean W M Gardeniers Journal: J Bone Joint Surg Am Date: 2005-11 Impact factor: 5.284
Authors: Morand Piert; Hans-Jürgen Machulla; Michael Jahn; Anke Stahlschmidt; Georg A Becker; Tilman T Zittel Journal: Eur J Nucl Med Mol Imaging Date: 2002-04-13 Impact factor: 9.236
Authors: M Beheshti; F M Mottaghy; F Paycha; F F F Behrendt; T Van den Wyngaert; I Fogelman; K Strobel; M Celli; S Fanti; F Giammarile; B Krause; W Langsteger Journal: Eur J Nucl Med Mol Imaging Date: 2015-07-23 Impact factor: 9.236
Authors: Jonathan P Dyke; Michael Synan; Paula Ezell; Douglas Ballon; Jennifer Racine; Roy K Aaron Journal: J Orthop Res Date: 2014-11-19 Impact factor: 3.494
Authors: Olivier P P Temmerman; Pieter G H M Raijmakers; Reina Kloet; Gerrit J J Teule; Ide C Heyligers; Adriaan A Lammertsma Journal: Rheumatol Int Date: 2012-07-26 Impact factor: 2.631