Literature DB >> 1854177

Synergistic effects between amoxicillin, metronidazole, and the hydroxymetabolite of metronidazole against Actinobacillus actinomycetemcomitans.

M J Pavicić1, A J van Winkelhoff, J de Graaff.   

Abstract

Interactions between metronidazole and amoxicillin, metronidazole and its hydroxymetabolite, and amoxicillin and the hydroxymetabolite of metronidazole were investigated with checkerboard titrations in combination with accurately determined MICs and MBCs. Actinobacillus actinomycetemcomitans was used as the test organism. Synergism was found for all three combinations. Fractional inhibitory concentration indices and fractional bactericidal concentration indices varied from 0.3 to 0.7. These synergistic interactions between these antibiotics may explain the efficacy of the combination of metronidazole and amoxicillin in various bacterial infections, including periodontal disease.

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Year:  1991        PMID： 1854177      PMCID： PMC245136          DOI： 10.1128/AAC.35.5.961

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Metronidazole concentrations in human plasma, saliva, and gingival crevice fluid after a single dose.

Authors:  M A Van Oosten; F J Notten; F H Mikx
Journal:  J Dent Res       Date:  1986-12       Impact factor: 6.116

2.  Chequerboard titrations: the influence of the composition of serial dilutions of antibiotics on the fractional inhibitory concentration index and fractional bactericidal concentration index.

Authors:  A M Horrevorts; C M de Ridder; M C Poot; M J de Jonge; J E Degener; G Dzoljic-Danilovic; M F Michel; K F Kerrebijn
Journal:  J Antimicrob Chemother       Date:  1987-01       Impact factor: 5.790

3.  Activity of metronidazole and its hydroxy metabolite against clinical isolates of Actinobacillus actinomycetemcomitans.

Authors:  H Jousimies-Somer; S Asikainen; P Suomala; P Summanen
Journal:  Oral Microbiol Immunol       Date:  1988-03

4.  Amoxycillin/clavulanic acid ('Augmentin') compared with a combination of aminopenicillin, aminoglycoside and metronidazole in the treatment of pelvic inflammatory disease.

Authors:  N Cirau-Vigneron; J Barrier; J Becue; M Chartier; J R Giraud; P Landes; J Leng; D Raudrant; J M Reme
Journal:  Pharmatherapeutica       Date:  1989

5.  Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents.

Authors:  C B Walker; J D Pappas; K Z Tyler; S Cohen; J M Gordon
Journal:  J Periodontol       Date:  1985-11       Impact factor: 6.993

6.  Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis.

Authors:  R L Mandell; S S Socransky
Journal:  J Periodontol       Date:  1988-06       Impact factor: 6.993

7.  Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis.

Authors:  A J van Winkelhoff; J P Rodenburg; R J Goené; F Abbas; E G Winkel; J de Graaff
Journal:  J Clin Periodontol       Date:  1989-02       Impact factor: 8.728

8.  The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.

Authors:  S J Eykyn
Journal:  Surgery       Date:  1983-01       Impact factor: 3.982

9.  The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adults.

Authors:  J Slots; L Bragd; M Wikström; G Dahlén
Journal:  J Clin Periodontol       Date:  1986-07       Impact factor: 8.728

Review 10.  Campylobacter pylori--therapy review.

Authors:  A T Axon
Journal:  Scand J Gastroenterol Suppl       Date:  1989
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  12 in total

1.  In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations.

Authors:  M J Pavicić; A J van Winkelhoff; J de Graaff
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

Review 2.  [The GTR technic within the framework of combined periodontal-orthodontic treatments. A case report].

Authors:  M Stelzel; L Flores-de-Jacoby
Journal:  Fortschr Kieferorthop       Date:  1995-11

Review 3.  Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.

Authors:  K C Lamp; C D Freeman; N E Klutman; M K Lacy
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

4.  Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model.

Authors:  Geisla M S Soares; Flavia Teles; Jacqueline R Starr; Magda Feres; Michele Patel; Lynn Martin; Ricardo Teles
Journal:  Antimicrob Agents Chemother       Date:  2015-03-02       Impact factor: 5.191

5.  Drug-Drug Interaction Discovery: Kernel Learning from Heterogeneous Similarities.

Authors:  Devendra Singh Dhami; Gautam Kunapuli; Mayukh Das; David Page; Sriraam Natarajan
Journal:  Smart Health (Amst)       Date:  2018-07-07

Review 6.  Metronidazole. A therapeutic review and update.

Authors:  C D Freeman; N E Klutman; K C Lamp
Journal:  Drugs       Date:  1997-11       Impact factor: 9.546

7.  Effect of Exposure to Portland Cement Dust on the Periodontal Status and on the Outcome of Non-Surgical Periodontal Therapy.

Authors:  Alaa Abdelhamid
Journal:  Int J Health Sci (Qassim)       Date:  2016-07

8.  In vitro activity of azithromycin compared with that of erythromycin against Actinobacillus actinomycetemcomitans.

Authors:  R Pajukanta; S Asikainen; M Saarela; S Alaluusua; H Jousimies-Somer
Journal:  Antimicrob Agents Chemother       Date:  1992-06       Impact factor: 5.191

9.  In vitro susceptibility of Helicobacter pylori to several antimicrobial combinations.

Authors:  M J Pavicić; F Namavar; T Verboom; A J van Winkelhoff; J De Graaff
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

Review 10.  The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.

Authors:  Dina Zandbergen; Dagmar Else Slot; Richard Niederman; Fridus A Van der Weijden
Journal:  BMC Oral Health       Date:  2016-02-29       Impact factor: 2.757
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