Literature DB >> 18541426

Novel fluorinated acridone derivatives. Part 1: synthesis and evaluation as potential anticancer agents.

Olugbeminiyi O Fadeyi1, Saudat T Adamson, E Lewis Myles, Cosmas O Okoro.   

Abstract

We report on the synthesis of a novel series of fluorinated acridones from 5-trifluoromethyl-1,3-cyclohexanedione. The cytotoxic activities of the compounds were studied in several cancer cells. Compounds 9a, 9c, 9e, 9f, and 9h exhibited significant anticancer activities in selected cell lines. Compound 9c is the most active showing GI(50) that ranged in values from 0.13 to 26 microM, covering a wide range of cancer cell lines.

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Year:  2008        PMID： 18541426     DOI： 10.1016/j.bmcl.2008.05.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Photochemical synthesis and anticancer activity of barbituric acid, thiobarbituric acid, thiosemicarbazide, and isoniazid linked to 2-phenyl indole derivatives.

Authors:  S Vijaya Laxmi; G Rajitha; B Rajitha; Asha Jyothi Rao
Journal:  J Chem Biol       Date:  2015-11-17

2.  Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.

Authors:  Lorena Infante Lara; Alexis Sledge; Amine Laradji; Cosmas O Okoro; Neil Osheroff
Journal:  Bioorg Med Chem Lett       Date:  2016-12-05       Impact factor: 2.823

Review 3.  An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases.

Authors:  João Paulo B Lopes; Luana Silva; Diogo S Lüdtke
Journal:  RSC Med Chem       Date:  2021-09-08

4.  5,7-Dibromo-3-trifluoro-methyl-3,4-dihydro-acridin-1(2H)-one.

Authors:  Cosmas O Okoro; Tasneem Siddiquee; Olugbeminiyi O Fadeyi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-16

5.  A facile synthesis of N-H- and N-substituted acridine-1,8-diones under sonic condition.

Authors:  S Sudha; M A Pasha
Journal:  ScientificWorldJournal       Date:  2013-12-31

6.  Sustainable Access to Acridin-9-(10H)ones with an Embedded m-Terphenyl Moiety Based on a Three-Component Reaction.

Authors:  Damiano Rocchi; Jorge Gómez-Carpintero; Juan F González; J Carlos Menéndez
Journal:  Molecules       Date:  2020-11-27       Impact factor: 4.411

7.  Highly bioactive novel aryl-, benzyl-, and piperazine-selenoureas: synthesis, structural characterization and in vitro biological evaluation.

Authors:  Ziad Moussa; Ranem Kaddoura; Haythem A Saadeh; Nael Abutaha; Saleh A Ahmed
Journal:  Heliyon       Date:  2022-09-21

8.  Synthesis of novel cytotoxic tetracyclic acridone derivatives and study of their molecular docking, ADMET, QSAR, bioactivity and protein binding properties.

Authors:  Rajkumar Veligeti; Rajesh Bagepalli Madhu; Jayashree Anireddy; Visweswara Rao Pasupuleti; Vijaya Kumar Reddy Avula; Krishna S Ethiraj; Srinivas Uppalanchi; Sivaprasad Kasturi; Yogeeswari Perumal; Hasitha Shilpa Anantaraju; Naveen Polkam; Mallilkarjuna Reddy Guda; Swetha Vallela; Grigory Vasilievich Zyryanov
Journal:  Sci Rep       Date:  2020-11-26       Impact factor: 4.379
  8 in total

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