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Literature DB >> 185409

Polyoma genome in hamster BHK-21-C13 cells: integration into cellular DNA and induction of the viral replication.

Abstract

When grown at 39.5 degrees C, BHK-21 C-13 cells transformed by A gene mutants of polyoma virus contain viral sequences that are predominantly associated with cellular DNA pelleted in the Hirt lysis procedure. At this temperature, in cells that are inducible for viral DNA replication (Folk, 1973), the majority of the viral genomes are covalently joined with cellular DNA's containing repetitious sequences. Upon a shift to 31 degrees C, free viral genomes appear and are replicated. Coupled with the replication of the free viral genomes at 31 degrees C is an increase in the viral genomes associated with cellular DNA.

Entities: Disease Species

Mesh：

Substances：
DNA, Neoplasm
DNA, Viral

Year: 1976 PMID： 185409 PMCID： PMC354974

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

31 in total

1. CELL-TRANSFORMING ABILITY OF A TEMPERATURE-SENSITIVE MUTANT OF POLYOMA VIRUS.

Authors: M FRIED
Journal: Proc Natl Acad Sci U S A Date: 1965-03 Impact factor: 11.205

2. Covalent integration of viral DNA into cell DNA in hamster cells transformed by an avian adenovirus.

Authors: A J Bellett
Journal: Virology Date: 1975-06 Impact factor: 3.616

3. Function of simian virus 40 gene A in transforming infection.

Authors: P Tegtmeyer
Journal: J Virol Date: 1975-03 Impact factor: 5.103

4. Transformation of primate and rodent cells by temperature-sensitive mutants of SV40.

Authors: J S Butel; J S Brugge; C A Noonan
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

5. The semiautonomous replicon: a molecular model for the oncogenicity of SV40.

Authors: R G Martin; J Y Chou; J Avila; R Saral
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

6. Simian virus 40 gene A function and maintenance of transformation.

Authors: M Osborn; K Weber
Journal: J Virol Date: 1975-03 Impact factor: 5.103

7. Selective extraction of polyoma DNA from infected mouse cell cultures.

Authors: B Hirt
Journal: J Mol Biol Date: 1967-06-14 Impact factor: 5.469

8. Activation of production of infectious tumor virus SV40 in heterokaryon cultures.

Authors: H Koprowski; F C Jensen; Z Steplewski
Journal: Proc Natl Acad Sci U S A Date: 1967-07 Impact factor: 11.205

9. Isolation of high-molecular-weight DNA from mammalian cells.

Authors: M Gross-Bellard; P Oudet; P Chambon
Journal: Eur J Biochem Date: 1973-07-02

10. Iodination of DNA. Studies of the reaction and iodination of papovavirus DNA.

Authors: D M Anderson; W R Folk
Journal: Biochemistry Date: 1976-03-09 Impact factor: 3.162

7 in total

1. State of the viral DNA in rat cells transformed by polyma virus. II. Identification of the cells containing nonintegrated viral DNA and the effect of viral mutations.

Authors: D Zouzias; I Prasad; C Basilico
Journal: J Virol Date: 1977-10 Impact factor: 5.103

2. "Onion skin" replication of integrated polyoma virus DNA and flanking sequences in polyoma-transformed rat cells: termination within a specific cellular DNA segment.

Authors: N Baran; A Neer; H Manor
Journal: Proc Natl Acad Sci U S A Date: 1983-01 Impact factor: 11.205

6. Comparison of the DNA sequence of the Crawford small-plaque variant of polyomavirus with those of polyomaviruses A2 and strain 3.

Authors: V M Rothwell; W R Folk
Journal: J Virol Date: 1983-11 Impact factor: 5.103

7. Nucleotide sequence changes in polyoma virus A gene mutants.

Authors: T Thomas; P Vollmer; W R Folk
Journal: J Virol Date: 1981-03 Impact factor: 5.103