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Literature DB >> 18537741

Computational analyses of TBC protein family in eukaryotes.

Xinjiao Gao¹, Changjiang Jin, Yu Xue, Xuebiao Yao.

Abstract

Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.

Entities: Gene

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Year: 2008 PMID： 18537741 DOI： 10.2174/092986608784567483

Source DB: PubMed Journal: Protein Pept Lett ISSN： 0929-8665 Impact factor: 1.890

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Cited

7 in total

1. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.

Authors: Lesly De Arras; Ivana V Yang; Brad Lackford; David W H Riches; Rytis Prekeris; Jonathan H Freedman; David A Schwartz; Scott Alper
Journal: J Immunol Date: 2012-02-06 Impact factor: 5.422

2. Mutations in TBC1D24, a gene associated with epilepsy, also cause nonsyndromic deafness DFNB86.

Authors: Atteeq U Rehman; Regie Lyn P Santos-Cortez; Robert J Morell; Meghan C Drummond; Taku Ito; Kwanghyuk Lee; Asma A Khan; Muhammad Asim R Basra; Naveed Wasif; Muhammad Ayub; Rana A Ali; Syed I Raza; Deborah A Nickerson; Jay Shendure; Michael Bamshad; Saima Riazuddin; Neil Billington; Shaheen N Khan; Penelope L Friedman; Andrew J Griffith; Wasim Ahmad; Sheikh Riazuddin; Suzanne M Leal; Thomas B Friedman
Journal: Am J Hum Genet Date: 2014-01-02 Impact factor: 11.025

3. A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24.

Authors: Mark A Corbett; Melanie Bahlo; Lachlan Jolly; Zaid Afawi; Alison E Gardner; Karen L Oliver; Stanley Tan; Amy Coffey; John C Mulley; Leanne M Dibbens; Walid Simri; Adel Shalata; Sara Kivity; Graeme D Jackson; Samuel F Berkovic; Jozef Gecz
Journal: Am J Hum Genet Date: 2010-09-10 Impact factor: 11.025

4. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

Authors: Doris Popovic; Masato Akutsu; Ivana Novak; J Wade Harper; Christian Behrends; Ivan Dikic
Journal: Mol Cell Biol Date: 2012-02-21 Impact factor: 4.272

Computational analyses of TBC protein family in eukaryotes.

1. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.

2. Mutations in TBC1D24, a gene associated with epilepsy, also cause nonsyndromic deafness DFNB86.

3. A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24.

4. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

5. The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles.

6. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins.

7. Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy.