| Literature DB >> 18537250 |
Hui Wang1, Carlos Tassa, Peter A Jacobi.
Abstract
Alkyne acids 11 were prepared in an enantioselective fashion from allylic ester derivatives 18 or 20 by Ireland-Claisen rearrangement, followed by Si-assisted elimination of HBr. The title compounds are attractive ring D synthons for an ongoing synthesis of cobyric acid.Entities:
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Year: 2008 PMID： 18537250 PMCID： PMC2575186 DOI： 10.1021/ol800985m
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005