Literature DB >> 18535081

LOT: a tool for linkage analysis of ordinal traits for pedigree data.

Meizhuo Zhang1, Rui Feng, Xiang Chen, Buqu Hu, Heping Zhang.   

Abstract

SUMMARY: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. AVAILABILITY: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/

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Year:  2008        PMID： 18535081      PMCID： PMC2566542          DOI： 10.1093/bioinformatics/btn258

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  9 in total

1.  Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study.

Authors:  Larry D Atwood; Nancy L Heard-Costa; L Adrienne Cupples; Cashell E Jaquish; Peter W F Wilson; Ralph B D'Agostino
Journal:  Am J Hum Genet       Date:  2002-09-27       Impact factor: 11.025

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Journal:  Hum Hered       Date:  2004       Impact factor: 0.444

3.  Linkage analysis of ordinal traits for pedigree data.

Authors:  Rui Feng; James F Leckman; Heping Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-17       Impact factor: 11.205

4.  Ascertainment adjustment in genetic studies of ordinal traits.

Authors:  Rui Feng; Heping Zhang
Journal:  Hum Genet       Date:  2006-03-10       Impact factor: 4.132

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Journal:  Am J Epidemiol       Date:  1990-06       Impact factor: 4.897

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Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

7.  Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.

Authors:  E Lander; L Kruglyak
Journal:  Nat Genet       Date:  1995-11       Impact factor: 38.330

8.  Linkage of early-onset familial breast cancer to chromosome 17q21.

Authors:  J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

9.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025
  9 in total
  2 in total

1.  Statistical Analysis in Genetic Studies of Mental Illnesses.

Authors:  Heping Zhang
Journal:  Stat Sci       Date:  2011-01-01       Impact factor: 2.901

2.  Bayesian linkage analysis of categorical traits for arbitrary pedigree designs.

Authors:  Abra Brisbin; Myrna M Weissman; Abby J Fyer; Steven P Hamilton; James A Knowles; Carlos D Bustamante; Jason G Mezey
Journal:  PLoS One       Date:  2010-08-26       Impact factor: 3.240
  2 in total

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