OBJECTIVE: To study the refractory cases of Kawasaki disease (KD) and identify potential risk factors in patients in whom standard therapy fails. STUDY DESIGN: A retrospective chart review of patients with KD admitted from January 1, 2002, through December 31, 2006. Demographic, clinical, laboratory, echocardiographic, and therapeutic data were recorded. RESULTS: Of 196 patients, 40 (20%) needed re-treatment. The number of refractory cases were 7 (14.3%), 6 (17.1%), 11(28.9%), 10 (24.4%), and 6 (17.6%) for 2002 to 2006, respectively. There were no significant differences in age, sex, ethnicity, number of days with symptoms at diagnosis, white blood cell count, erythrocyte sedimentation rate (ESR), or C-reactive protein (CRP). Refractory patients had higher band counts (22.7% vs 7%), lower albumin levels (3 vs 3.4), and a higher number of abnormal echocardiography results at diagnosis (80% vs 16.1%). CONCLUSIONS: An elevated band count, low albumin level, and an abnormal initial echocardiography result can be useful tools to identify patients at risk for a more complicated clinical course.
OBJECTIVE: To study the refractory cases of Kawasaki disease (KD) and identify potential risk factors in patients in whom standard therapy fails. STUDY DESIGN: A retrospective chart review of patients with KD admitted from January 1, 2002, through December 31, 2006. Demographic, clinical, laboratory, echocardiographic, and therapeutic data were recorded. RESULTS: Of 196 patients, 40 (20%) needed re-treatment. The number of refractory cases were 7 (14.3%), 6 (17.1%), 11(28.9%), 10 (24.4%), and 6 (17.6%) for 2002 to 2006, respectively. There were no significant differences in age, sex, ethnicity, number of days with symptoms at diagnosis, white blood cell count, erythrocyte sedimentation rate (ESR), or C-reactive protein (CRP). Refractory patients had higher band counts (22.7% vs 7%), lower albumin levels (3 vs 3.4), and a higher number of abnormal echocardiography results at diagnosis (80% vs 16.1%). CONCLUSIONS: An elevated band count, low albumin level, and an abnormal initial echocardiography result can be useful tools to identify patients at risk for a more complicated clinical course.
Authors: Daniel Phadke; Sonali S Patel; Samuel R Dominguez; Heather Heizer; Marsha S Anderson; Mary P Glode; Pei-Ni Jone Journal: Pediatr Cardiol Date: 2015-05-21 Impact factor: 1.655
Authors: Jae-Jung Kim; Young Mi Hong; Sin Weon Yun; Myung Ki Han; Kyung-Yil Lee; Min Seob Song; Hyoung-Doo Lee; Dong Soo Kim; Sejung Sohn; Kee-Soo Ha; Soo-Jong Hong; Kwi-Joo Kim; In-Sook Park; Gi Young Jang; Jong-Keuk Lee Journal: Pediatr Cardiol Date: 2011-11-22 Impact factor: 1.655
Authors: Lynn A Sleeper; L Luann Minich; Brian M McCrindle; Jennifer S Li; Wilbert Mason; Steven D Colan; Andrew M Atz; Beth F Printz; Annette Baker; Victoria L Vetter; Jane W Newburger Journal: J Pediatr Date: 2010-12-18 Impact factor: 4.406
Authors: Young-Sun Do; Ki-Won Kim; Jin-Kyong Chun; Byung Ho Cha; Mee Kyung Namgoong; Hae Yong Lee Journal: Korean Circ J Date: 2010-05-27 Impact factor: 3.243