OBJECTIVE: To investigate the prevalence of both calcium metabolism alterations and bone defects in children with celiac disease (CD). STUDY DESIGN: We studied 54 untreated patients with CD (mean age, 7 years). We compared the serum concentration of calcium, magnesium, 25(OH)vitamin D3, alkaline phosphatase, and parathyroid hormone (PTH) of patients with CD with those of 60 healthy children. Children with CD with 2 laboratory alterations underwent DEXA examination, which was evaluated after 6 months of a gluten-free diet (GFD). RESULTS: The calcium and the 25(OH)vitamin D3 levels were lower in children with CD than in control subjects, and the PTH level was higher in children with CD than in control subjects (P < .001). Hyperparathyroidism was found in 29 children with CD. Twenty patients tested positive for 2 laboratory alterations, and 10 of them were osteopenic. After 6 months of GFD calcium, 25(OH)vit.D3 and PTH levels normalized, with the improvement of bone mineral density. CONCLUSIONS: Calcium metabolism defects are common in untreated children with CD, and they returned to normal after GFD. A detailed, time-consuming, and expensive study of bone metabolism is not necessary in children with CD shortly exposed to gluten who follow the GFD.
OBJECTIVE: To investigate the prevalence of both calcium metabolism alterations and bone defects in children with celiac disease (CD). STUDY DESIGN: We studied 54 untreated patients with CD (mean age, 7 years). We compared the serum concentration of calcium, magnesium, 25(OH)vitamin D3, alkaline phosphatase, and parathyroid hormone (PTH) of patients with CD with those of 60 healthy children. Children with CD with 2 laboratory alterations underwent DEXA examination, which was evaluated after 6 months of a gluten-free diet (GFD). RESULTS: The calcium and the 25(OH)vitamin D3 levels were lower in children with CD than in control subjects, and the PTH level was higher in children with CD than in control subjects (P < .001). Hyperparathyroidism was found in 29 children with CD. Twenty patients tested positive for 2 laboratory alterations, and 10 of them were osteopenic. After 6 months of GFD calcium, 25(OH)vit.D3 and PTH levels normalized, with the improvement of bone mineral density. CONCLUSIONS:Calcium metabolism defects are common in untreated children with CD, and they returned to normal after GFD. A detailed, time-consuming, and expensive study of bone metabolism is not necessary in children with CD shortly exposed to gluten who follow the GFD.
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638
Authors: Norelle R Reilly; Benjamin Lebwohl; Kaziwe Mollazadegan; Karl Michaëlsson; Peter H R Green; Jonas F Ludvigsson Journal: J Pediatr Date: 2015-11-14 Impact factor: 4.406
Authors: Mostafa Abdel-Aziz El-Hodhod; Iman Ali El-Agouza; Hala Abdel-Al; Noha Samir Kabil; Khaled Abd El-Moez Bayomi Journal: ISRN Pediatr Date: 2012-06-07
Authors: Stefano Pantaleoni; Massimo Luchino; Alessandro Adriani; Rinaldo Pellicano; Davide Stradella; Davide Giuseppe Ribaldone; Nicoletta Sapone; Gian Carlo Isaia; Marco Di Stefano; Marco Astegiano Journal: ScientificWorldJournal Date: 2014-10-14