Literature DB >> 18524420

A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.

Jinbing Liu1, Rihui Cao, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song.   

Abstract

A series of alkylidenethiosemicarbazide compounds were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that most of the synthesized compounds exhibited significant inhibitory activities. Especially, compound 1f was found to be the most potent inhibitor with IC(50) value of 0.086 microM, suggesting that further development of such compounds may be of interest.

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Year:  2008        PMID： 18524420     DOI： 10.1016/j.ejmech.2008.04.002

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  13 in total

1.  Anticholinesterase and antityrosinase activities of ten piper species from malaysia.

Authors:  Wan Mohd Nuzul Hakimi Wan Salleh; Nur Athirah Hashim; Farediah Ahmad; Khong Heng Yen
Journal:  Adv Pharm Bull       Date:  2014-12-31

2.  Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Authors:  Nayara Cristina Fonseca; Luana Faria da Cruz; Filipe da Silva Villela; Glaécia Aparecida do Nascimento Pereira; Jair Lage de Siqueira-Neto; Danielle Kellar; Brian M Suzuki; Debalina Ray; Thiago Belarmino de Souza; Ricardo José Alves; Policarpo Ademar Sales Júnior; Alvaro José Romanha; Silvane Maria Fonseca Murta; James H McKerrow; Conor R Caffrey; Renata Barbosa de Oliveira; Rafaela Salgado Ferreira
Journal:  Antimicrob Agents Chemother       Date:  2015-02-23       Impact factor: 5.191

3.  1-(4-Ethoxy-benzo-yl)-4-(4-methoxy-phen-yl)thiosemicarbazide.

Authors:  Saira Khanum; Muhammad Farman; Nasim H Rama; Shahid Hameed; Peter G Jones
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-03

4.  1-(2-Hy-droxy-eth-yl)-3-(3-meth-oxy-phen-yl)thio-urea.

Authors:  Hyeong Choi; Yong Suk Shim; Byung Hee Han; Sung Kwon Kang; Chang Keun Sung
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-04

5.  1-(4-Hy-droxy-phen-yl)-3-(3,4,5-tri-methoxy-phen-yl)thio-urea.

Authors:  Hyeong Choi; Byung Hee Han; Yong Suk Shim; Sung Kwon Kang; Chang Keun Sung
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-27

6.  Crystal structure of a 1,1,2,2-tetra-chloro-ethane-solvated hydrazinecarbo-thio-amide compound.

Authors:  Sayed Riyadh; David L Hughes; Musa A Said
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-08-01

Review 7.  Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.

Authors:  Thanigaimalai Pillaiyar; Manoj Manickam; Vigneshwaran Namasivayam
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

8.  Dopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities.

Authors:  Arunadevi Mani; Anis Ahamed; Daoud Ali; Saud Alarifi; Idhayadhulla Akbar
Journal:  Drug Des Devel Ther       Date:  2021-02-23       Impact factor: 4.162

9.  4-Arylthiosemicarbazide derivatives as a new class of tyrosinase inhibitors and anti-Toxoplasma gondii agents.

Authors:  Adrian Bekier; Lidia Węglińska; Agata Paneth; Piotr Paneth; Katarzyna Dzitko
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

10.  Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors.

Authors:  Joonhyeok Choi; Jun-Goo Jee
Journal:  Int J Mol Sci       Date:  2015-12-02       Impact factor: 5.923
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