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Literature DB >> 18523842

Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.

Adil Astulla¹, Kazumasa Zaima, Yosuke Matsuno, Yusuke Hirasawa, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita.

Abstract

Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

Entities: Chemical Species

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Year: 2008 PMID： 18523842 DOI： 10.1007/s11418-008-0259-7

Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343

20 in total

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2. Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa.

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Authors: Hicham Berrougui; Carmen Martín-Cordero; Abdelouahed Khalil; Mohammed Hmamouchi; Abdelkader Ettaib; Elisa Marhuenda; María Dolores Herrera
Journal: Pharmacol Res Date: 2006-05-01 Impact factor: 7.658

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Authors: D S Grosso; A M Gawienowski
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6. Peganum harmala: its use in certain dermatoses.

Authors: M El-Saad El-Rifaie
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7. An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L. seeds extract and its beta-carboline alkaloids.

Authors: Armin Madadkar Sobhani; Sultan-Ahmad Ebrahimi; Massoud Mahmoudian
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8. Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso.

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Review 9. beta-Carbolines, psychoactive compounds in the mammalian body. Part II: Effects.

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Review 5. Antibacterial, Antifungal, Antiviral, and Antiparasitic Activities of Peganum harmala and Its Ingredients: A Review.

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6. An alternative paradigm for the role of antimalarial plants in Africa.

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Journal: ScientificWorldJournal Date: 2012-04-19

7. Biotransformation of perfumery terpenoids, (-)-ambrox® by a fungal culture Macrophomina phaseolina and a plant cell suspension culture of Peganum harmala.

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8. Novel mechanism of harmaline on inducing G2/M cell cycle arrest and apoptosis by up-regulating Fas/FasL in SGC-7901 cells.

Authors: Yihai Wang; Chunhua Wang; Chenguang Jiang; Hong Zeng; Xiangjiu He
Journal: Sci Rep Date: 2015-12-18 Impact factor: 4.379

9. The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype.

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Journal: PeerJ Date: 2013-10-01 Impact factor: 2.984

Review 10. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids.

Authors: Milad Moloudizargari; Peyman Mikaili; Shahin Aghajanshakeri; Mohammad Hossein Asghari; Jalal Shayegh
Journal: Pharmacogn Rev Date: 2013-07