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Literature DB >> 16784851

Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa.

Hiroshi Morita¹, Toru Iizuka, Chee-Yan Choo, Kit-Lam Chan, Koichi Takeya, Jun'ichi Kobayashi.

Abstract

A cyclic octapeptide, cyclosquamosin B (2), isolated from the seeds of Annona squamosa showed a vasorelaxant effect on rat aorta. It showed a slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with/without endothelium. It showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, but moderately inhibition effect on NE-induced contraction in the presence of nicardipine. These results showed that the vasorelaxant effect by 2 might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels.

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Year: 2006 PMID： 16784851 DOI： 10.1016/j.bmcl.2006.06.008

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

13 in total

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4. Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery.

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Journal: J Nat Med Date: 2011-10-28 Impact factor: 2.343

Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa.

1. Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery.

2. Studies on the constituents from the fruits of Phaleria macrocarpa.

3. Four new Amaryllidaceae alkaloids from Zephyranthes candida.

4. Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery.

5. Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma.

6. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.

7. Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae).

Review 8. Vasodilator compounds derived from plants and their mechanisms of action.

9. N-cyanomethylnorboldine: a new aporphine isolated from Alseodaphne perakensis (Lauraceae).

10. Lancifoliaine, a new bisbenzylisoquinoline from the bark of Litsea lancifolia.