| Literature DB >> 18517255 |
Ya Zhou1, Aaron B Beeler, Sanghyun Cho, Yuehong Wang, Scott G Franzblau, John K Snyder.
Abstract
The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.Entities:
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Year: 2008 PMID： 18517255 DOI： 10.1021/cc800038r
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766