Literature DB >> 18514965

A common polymorphism is associated with body mass index in Uyghur population.

Jun Zhang1, Rong Lin, Fen Wang, Ming Lu, Ren-yong Lin, Shi-zhen Wang, Hao Wen, Li Jin, Xiao-feng Wang.   

Abstract

We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population. We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age.

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Year:  2008        PMID： 18514965     DOI： 10.1016/j.diabres.2008.03.022

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  9 in total

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8.  The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

Authors:  Jan Bressler; Myriam Fornage; Craig L Hanis; Wen Hong Linda Kao; Cora E Lewis; Ruth McPherson; Robert Dent; Thomas H Mosley; Len A Pennacchio; Eric Boerwinkle
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9.  Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.

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  9 in total

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