Literature DB >> 18513520

Achieving rapid reperfusion with primary percutaneous coronary intervention remains a challenge: insights from American Heart Association's Get With the Guidelines program.

Rajendra H Mehta1, Vincent J Bufalino, Wenqin Pan, Adrian F Hernandez, Christopher P Cannon, Gregg C Fonarow, Eric D Peterson.   

Abstract

BACKGROUND: The speed of reperfusion (door-to-balloon [D2B] time) is a well established performance metric for patients with ST-elevation myocardial infarction. Although preferably D2B times should be <or=90 minutes, it is unclear how consistently this is achieved in community practice, particularly in women, elderly people, and minorities.
METHODS: We used the American Heart Association Get With the Guidelines database to study D2B times at 254 participating United States sites (2002-2006). Median D2B time and percentage of compliance with goal (percutaneous coronary interventions [PCI] <or=90 minutes) were assessed overall, over time, and among patient subgroups associated with the greatest delay in this time (older patients, women, and minorities). Standard generalized estimating equation was used to assess continuous trend, percentage of compliance (PCI <or=90 minutes) over time, and disparities in care based on race, sex, and age.
RESULTS: Over the study period, 10965 patients with ST-elevation myocardial infarction who met eligibility criteria received primary PCI (36% aged >or=65 years, 27% female, and 17% nonwhite). The overall median D2B time was 96 minutes (interquartile range [IQR] 69-140 minutes). Only 44.8% of cases had D2B <or=90 minutes. Median D2B time improved over the study period (108 minutes at baseline [fourth quarter of 2002] to 82 minutes by the last study quarter [third quarter of 2006], adjusted P = .001). The percentage achieving D2B <or=90 minutes also improved (36.2%-58.8%, adjusted P = .003). Relative to their peers, patients aged >or=65 years (103 [IQR 74-153] vs 93 [IQR 67-133] minutes), women (103 [IQR 73-154] vs 94 [IQR 68-135] minutes), and minorities (108 [IQR 77-162] vs 95 [IQR 68-136] minutes) had significantly longer median D2B times. These subgroup disparities in the D2B persisted over the study period as compared with their peers.
CONCLUSION: The median D2B times with primary PCI have improved modestly in hospitals participating in the American Heart Association Get With the Guidelines program over the last few years but remain below ideal levels. The D2B times are particularly delayed in the elderly people, women, and minority populations; an issue that has persisted over time. These results highlight the ongoing need for national myocardial infarction quality improvement initiatives.

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Year:  2008        PMID: 18513520     DOI: 10.1016/j.ahj.2008.01.010

Source DB:  PubMed          Journal:  Am Heart J        ISSN: 0002-8703            Impact factor:   4.749


  20 in total

1.  Acute coronary syndromes: Reducing door-to-balloon time for STEMI--success at a price.

Authors:  Nihar R Desai; David A Morrow
Journal:  Nat Rev Cardiol       Date:  2012-07-03       Impact factor: 32.419

2.  Data feedback reduces door-to-balloon time in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Authors:  Jeng-Feng Lin; Shun-Yi Hsu; Semon Wu; Chiau-Suong Liau; Heng-Chia Chang; Chih-Jen Liu; Hsuan-Li Huang; Yao-Tsan Ho; Shu-Li Weng; Yu-Lin Ko
Journal:  Heart Vessels       Date:  2010-10-27       Impact factor: 2.037

3.  Why and when PCI, why and when thrombolysis?: thrombolysis.

Authors:  Giovanni Melandri; Franco Semprini; Samuele Nanni; Daniela Calabrese; Fabio Vagnarelli; Angelo Branzi
Journal:  Intern Emerg Med       Date:  2008-11-01       Impact factor: 3.397

4.  Improving use of prehospital 12-lead ECG for early identification and treatment of acute coronary syndrome and ST-elevation myocardial infarction.

Authors:  Denise H Daudelin; Assaad J Sayah; Manlik Kwong; Marc C Restuccia; William A Porcaro; Robin Ruthazer; Jessica D Goetz; William M Lane; Joni R Beshansky; Harry P Selker
Journal:  Circ Cardiovasc Qual Outcomes       Date:  2010-05

5.  Acute coronary syndrome in the elderly: the Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome registry.

Authors:  Ahmad Syadi Mahmood Zuhdi; Wan Azman Wan Ahmad; Rafdzah Ahmad Zaki; Jeevitha Mariapun; Rosli Mohd Ali; Norashikin Md Sari; Muhammad Dzafir Ismail; Sim Kui Hian
Journal:  Singapore Med J       Date:  2015-10-16       Impact factor: 1.858

6.  Quality of care for acute myocardial infarction in 58 U.S. emergency departments.

Authors:  Chu-Lin Tsai; David J Magid; Ashley F Sullivan; James A Gordon; Rainu Kaushal; P Michael Ho; Pamela N Peterson; David Blumenthal; Carlos A Camargo
Journal:  Acad Emerg Med       Date:  2010-09       Impact factor: 3.451

7.  Sex differences in reperfusion in young patients with ST-segment-elevation myocardial infarction: results from the VIRGO study.

Authors:  Gail D'Onofrio; Basmah Safdar; Judith H Lichtman; Kelly M Strait; Rachel P Dreyer; Mary Geda; John A Spertus; Harlan M Krumholz
Journal:  Circulation       Date:  2015-03-19       Impact factor: 29.690

8.  Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry.

Authors:  Lynette M Brown; Hubert Chen; Scott Halpern; Darren Taichman; Michael D McGoon; Harrison W Farber; Adaani E Frost; Theodore G Liou; Michelle Turner; Kathy Feldkircher; Dave P Miller; C Gregory Elliott
Journal:  Chest       Date:  2011-03-10       Impact factor: 9.410

9.  Factors associated with delayed use or nonuse of systemic corticosteroids in emergency department patients with acute asthma.

Authors:  Chu-Lin Tsai; Brian H Rowe; Ashley F Sullivan; Carlos A Camargo
Journal:  Ann Allergy Asthma Immunol       Date:  2009-10       Impact factor: 6.347

10.  [Delays in the management of acute coronary syndromes with ST-ST segment elevation in Ouagadougou and factors associated with an extension of these delays: a cross-sectional study about 43 cases collected in the CHU-Yalgado Ouédraogo].

Authors:  Nobila Valentin Yameogo; André Samadoulougou; Georges Millogo; Koudougou Jonas Kologo; Karim Kombassere; Boubacar Jean Yves Toguyeni; Patrice Zabsonre
Journal:  Pan Afr Med J       Date:  2012-12-30
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