OBJECTIVE: We evaluated the hypothesis that higher levels of total daily physical activity can eliminate the increased mortality rate associated with overweight and obesity. DESIGN: Population-based prospective cohort study. SETTING: Central Sweden. SUBJECTS: A total of 37,633 men at baseline 45-79 years of age and free of known cancer and cardiovascular disease and diabetes completed a self-administered life-style questionnaire, which included questions on body-mass index (BMI) and physical activity. During 9.7 years of follow-up, we identified a total of 4086 deaths. MAIN OUTCOME MEASURES: Mortality rate ratios (RRs). RESULTS: Compared to men who were lean (BMI < 25 kg m(-2)) and active (top tertile of total physical activity level) the multivariable adjusted RRs (95% confidence interval) of death from all causes were 1.44 (1.11-1.86) for obese (BMI > or = 30 kg m(-2)) and active men, 1.54 (1.34-1.77) for lean (BMI < 25 kg m(-2)) but inactive (bottom tertile) men, and 1.81 (1.48-2.23) for obese-inactive men. After excluding the first 3 years of follow-up, current and former smokers, those who had lost weight from age 20 years to age at baseline, and heavy manual workers, the adjusted RRs of death from all causes were 1.65 (1.20-2.27) for overweight-to-obese and active men, 2.15 (1.59-2.91) for lean-inactive men, and 2.04 (1.52-2.74) for overweight-to-obese and inactive men compared to lean-active men. CONCLUSIONS: We conclude that both overweight and physical inactivity are important predictors of mortality. Our findings do not support the hypothesis that a higher level of physical activity compensates the excess mortality associated with overweight and obesity.
OBJECTIVE: We evaluated the hypothesis that higher levels of total daily physical activity can eliminate the increased mortality rate associated with overweight and obesity. DESIGN: Population-based prospective cohort study. SETTING: Central Sweden. SUBJECTS: A total of 37,633 men at baseline 45-79 years of age and free of known cancer and cardiovascular disease and diabetes completed a self-administered life-style questionnaire, which included questions on body-mass index (BMI) and physical activity. During 9.7 years of follow-up, we identified a total of 4086 deaths. MAIN OUTCOME MEASURES: Mortality rate ratios (RRs). RESULTS: Compared to men who were lean (BMI < 25 kg m(-2)) and active (top tertile of total physical activity level) the multivariable adjusted RRs (95% confidence interval) of death from all causes were 1.44 (1.11-1.86) for obese (BMI > or = 30 kg m(-2)) and active men, 1.54 (1.34-1.77) for lean (BMI < 25 kg m(-2)) but inactive (bottom tertile) men, and 1.81 (1.48-2.23) for obese-inactive men. After excluding the first 3 years of follow-up, current and former smokers, those who had lost weight from age 20 years to age at baseline, and heavy manual workers, the adjusted RRs of death from all causes were 1.65 (1.20-2.27) for overweight-to-obese and active men, 2.15 (1.59-2.91) for lean-inactive men, and 2.04 (1.52-2.74) for overweight-to-obese and inactive men compared to lean-active men. CONCLUSIONS: We conclude that both overweight and physical inactivity are important predictors of mortality. Our findings do not support the hypothesis that a higher level of physical activity compensates the excess mortality associated with overweight and obesity.
Authors: Cari M Kitahara; Marjorie L McCullough; Silvia Franceschi; Sabina Rinaldi; Alicja Wolk; Gila Neta; Hans Olov Adami; Kristin Anderson; Gabriella Andreotti; Laura E Beane Freeman; Leslie Bernstein; Julie E Buring; Francoise Clavel-Chapelon; Lisa A De Roo; Yu-Tang Gao; J Michael Gaziano; Graham G Giles; Niclas Håkansson; Pamela L Horn-Ross; Vicki A Kirsh; Martha S Linet; Robert J MacInnis; Nicola Orsini; Yikyung Park; Alpa V Patel; Mark P Purdue; Elio Riboli; Kimberly Robien; Thomas Rohan; Dale P Sandler; Catherine Schairer; Arthur B Schneider; Howard D Sesso; Xiao-Ou Shu; Pramil N Singh; Piet A van den Brandt; Elizabeth Ward; Elisabete Weiderpass; Emily White; Yong-Bing Xiang; Anne Zeleniuch-Jacquotte; Wei Zheng; Patricia Hartge; Amy Berrington de González Journal: Thyroid Date: 2016-02 Impact factor: 6.568
Authors: Emma E McGee; Sarah S Jackson; Jessica L Petrick; Alison L Van Dyke; Hans-Olov Adami; Demetrius Albanes; Gabriella Andreotti; Laura E Beane-Freeman; Amy Berrington de Gonzalez; Julie E Buring; Andrew T Chan; Yu Chen; Gary E Fraser; Neal D Freedman; Yu-Tang Gao; Susan M Gapstur; J Michael Gaziano; Graham G Giles; Eric J Grant; Francine Grodstein; Patricia Hartge; Mazda Jenab; Cari M Kitahara; Synnove F Knutsen; Woon-Puay Koh; Susanna C Larsson; I-Min Lee; Linda M Liao; Juhua Luo; Roger L Milne; Kristine R Monroe; Marian L Neuhouser; Katie M O'Brien; Ulrike Peters; Jenny N Poynter; Mark P Purdue; Kim Robien; Dale P Sandler; Norie Sawada; Catherine Schairer; Howard D Sesso; Tracey G Simon; Rashmi Sinha; Rachael Stolzenberg-Solomon; Shoichiro Tsugane; Renwei Wang; Elisabete Weiderpass; Stephanie J Weinstein; Emily White; Alicja Wolk; Jian-Min Yuan; Anne Zeleniuch-Jacquotte; Xuehong Zhang; Bin Zhu; Katherine A McGlynn; Peter T Campbell; Jill Koshiol Journal: J Natl Cancer Inst Date: 2019-12-01 Impact factor: 13.506
Authors: Amy Berrington de Gonzalez; Patricia Hartge; James R Cerhan; Alan J Flint; Lindsay Hannan; Robert J MacInnis; Steven C Moore; Geoffrey S Tobias; Hoda Anton-Culver; Laura Beane Freeman; W Lawrence Beeson; Sandra L Clipp; Dallas R English; Aaron R Folsom; D Michal Freedman; Graham Giles; Niclas Hakansson; Katherine D Henderson; Judith Hoffman-Bolton; Jane A Hoppin; Karen L Koenig; I-Min Lee; Martha S Linet; Yikyung Park; Gaia Pocobelli; Arthur Schatzkin; Howard D Sesso; Elisabete Weiderpass; Bradley J Willcox; Alicja Wolk; Anne Zeleniuch-Jacquotte; Walter C Willett; Michael J Thun Journal: N Engl J Med Date: 2010-12-02 Impact factor: 91.245
Authors: James R Cerhan; Steven C Moore; Eric J Jacobs; Cari M Kitahara; Philip S Rosenberg; Hans-Olov Adami; Jon O Ebbert; Dallas R English; Susan M Gapstur; Graham G Giles; Pamela L Horn-Ross; Yikyung Park; Alpa V Patel; Kim Robien; Elisabete Weiderpass; Walter C Willett; Alicja Wolk; Anne Zeleniuch-Jacquotte; Patricia Hartge; Leslie Bernstein; Amy Berrington de Gonzalez Journal: Mayo Clin Proc Date: 2014-03 Impact factor: 7.616
Authors: Cari M Kitahara; Alan J Flint; Amy Berrington de Gonzalez; Leslie Bernstein; Michelle Brotzman; Robert J MacInnis; Steven C Moore; Kim Robien; Philip S Rosenberg; Pramil N Singh; Elisabete Weiderpass; Hans Olov Adami; Hoda Anton-Culver; Rachel Ballard-Barbash; Julie E Buring; D Michal Freedman; Gary E Fraser; Laura E Beane Freeman; Susan M Gapstur; John Michael Gaziano; Graham G Giles; Niclas Håkansson; Jane A Hoppin; Frank B Hu; Karen Koenig; Martha S Linet; Yikyung Park; Alpa V Patel; Mark P Purdue; Catherine Schairer; Howard D Sesso; Kala Visvanathan; Emily White; Alicja Wolk; Anne Zeleniuch-Jacquotte; Patricia Hartge Journal: PLoS Med Date: 2014-07-08 Impact factor: 11.069