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Literature DB >> 1851311

Salivary THC following cannabis smoking correlates with subjective intoxication and heart rate.

D B Menkes¹, R C Howard, G F Spears, E R Cairns.

Abstract

A cannabis smoking trial was conducted using paid volunteers. Subjective intoxication, measured using a visual analogue scale, was compared with heart rate and with salivary delta-9-tetrahydrocannabinol (THC) levels at various times after smoking a cigarette containing 11 mg THC. Subjective intoxication and heart rate elevation were significantly correlated with the log of salivary THC. Salivary THC levels are a sensitive index of recent cannabis smoking, and appear more closely linked with the effects of intoxication than do either blood or urine cannabinoid levels.

Entities: Chemical

Mesh：

Substances：
Dronabinol

Year: 1991 PMID： 1851311 DOI： 10.1007/bf02244217

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

8 in total

1. Determination of delta 9-tetrahydrocannabinol in human blood and saliva by high-performance liquid chromatography with amperometric detection.

Authors: L K Thompson; E J Cone
Journal: J Chromatogr Date: 1987-10-09

2. Detection of recent cannabis use by saliva delta 9-THC radioimmunoassay.

Authors: S J Gross; T E Worthy; L Nerder; E G Zimmermann; J R Soares; P Lomax
Journal: J Anal Toxicol Date: 1985 Jan-Feb Impact factor: 3.367

3. GC/MS and EMIT analyses for delta 9-tetrahydrocannabinol metabolites in plasma and urine of human subjects.

Authors: L J McBurney; B A Bobbie; L A Sepp
Journal: J Anal Toxicol Date: 1986 Mar-Apr Impact factor: 3.367

4. Interpretation of blood and urine cannabinoid concentrations.

Authors: A J McBay
Journal: J Forensic Sci Date: 1988-07 Impact factor: 1.832

5. Detection of delta 9-tetrahydrocannabinol in saliva of men by means of thin-layer chromatography and mass spectrometry.

Authors: W W Just; N Filipovic; G Werner
Journal: J Chromatogr Date: 1974-09-11

6. MANOVA method for analyzing repeated measures designs: an extensive primer.

Authors: R G O'Brien; M K Kaiser
Journal: Psychol Bull Date: 1985-03 Impact factor: 17.737

7. Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking.

Authors: A Ohlsson; J E Lindgren; A Wahlen; S Agurell; L E Hollister; H K Gillespie
Journal: Clin Pharmacol Ther Date: 1980-09 Impact factor: 6.875

8. The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.

Authors: H Ashton; J Golding; V R Marsh; J E Millman; J W Thompson
Journal: Br J Clin Pharmacol Date: 1981-11 Impact factor: 4.335

8 in total

7 in total

Review 1. Human cannabinoid pharmacokinetics.

Authors: Marilyn A Huestis
Journal: Chem Biodivers Date: 2007-08 Impact factor: 2.408

Salivary THC following cannabis smoking correlates with subjective intoxication and heart rate.

1. Determination of delta 9-tetrahydrocannabinol in human blood and saliva by high-performance liquid chromatography with amperometric detection.

2. Detection of recent cannabis use by saliva delta 9-THC radioimmunoassay.

3. GC/MS and EMIT analyses for delta 9-tetrahydrocannabinol metabolites in plasma and urine of human subjects.

4. Interpretation of blood and urine cannabinoid concentrations.

5. Detection of delta 9-tetrahydrocannabinol in saliva of men by means of thin-layer chromatography and mass spectrometry.

6. MANOVA method for analyzing repeated measures designs: an extensive primer.

7. Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking.

8. The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.

Review 1. Human cannabinoid pharmacokinetics.

2. Drug testing in oral fluid.

Review 3. Biomarkers for the effects of cannabis and THC in healthy volunteers.

Review 4. Current knowledge on cannabinoids in oral fluid.

5. A Large-Scale Naturalistic Examination of the Acute Effects of Cannabis on Pain.

6. The effects of cannabis use on physical health: A co-twin control study.

7. Psychoimmunology and infection.