Literature DB >> 18511748

Muscle disuse: adaptation of antioxidant systems is age dependent.

Chiao-nan Joyce Chen1, Holly M Brown-Borg, Sharlene G Rakoczy, LaDora V Thompson.   

Abstract

This study investigated the age effect on antioxidant adaptation to muscle disuse. Adult and old rats were randomized into 4 groups: weight bearing (control), 3 days of hind-limb unloading (HU), 7 days of HU, and 14 days of HU. Activities of Cu-Zn superoxide dismutase (SOD), catalase, and glutathione (GSH), as well as GSH peroxidase levels were measured in the soleus. Neither disuse nor aging changed the activity of Cu-Zn SOD. The old rats had greater GSH peroxidase activity, whereas the activity of catalase had a compensatory increase with disuse, independent of age. Reduced GSH level and total glutathione (tGSH) level had age-related change with disuse. In old rats, the GSH and tGSH levels were lower with disuse, whereas the levels remained stable with disuse in adult rats. The depletion of intracellular GSH and tGSH levels of muscles from aged animals with disuse may make aged muscles more susceptible to oxidative damage.

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Year:  2008        PMID： 18511748      PMCID： PMC2670877          DOI： 10.1093/gerona/63.5.461

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  39 in total

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Authors:  H M Brown-Borg; S G Rakoczy
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Review 7.  Oxidative stress and disuse muscle atrophy.

Authors:  Scott K Powers; Andreas N Kavazis; Joseph M McClung
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Review 6.  The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.

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7.  Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats.

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Journal:  Exp Gerontol       Date:  2010-08-10       Impact factor: 4.032

8.  Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress.

Authors:  Chiao-Nan Joyce Chen; Holly M Brown-Borg; Sharlene G Rakoczy; Deborah A Ferrington; LaDora V Thompson
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-12-16       Impact factor: 6.053

9.  Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.

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Journal:  FASEB J       Date:  2016-02-02       Impact factor: 5.191
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