Literature DB >> 18511477

Rapid identification of infants for antiretroviral therapy in a resource poor setting: the Kenya experience.

Samoel Khamadi1, Vincent Okoth, Raphael Lihana, Judi Nabwera, Jackson Hungu, Fred Okoth, Kizito Lubano, Matilu Mwau.   

Abstract

In Kenya, HIV diagnosis is not routinely carried out in infants, and yet rapid diagnosis could improve access to lifesaving interventions. A cheap and readily accessible service can resolve this problem, if feasible. In this pilot study the feasibility and costs of provision of an infant HIV diagnosis service in Kenya are evaluated. Dried blood spots (DBS) were collected from infants exposed to HIV, sent to a central testing laboratory and tested using the Roche Amplicor v. 1.5 DNA PCR kit. The results were then dispatched to health facilities within a week. A total of 15.4% of the samples tested HIV+ despite the widespread access to prevention of mother to child transmission (PMTCT) programs in Kenya. The cost per test at 21.50 USD is prohibitive and will limit access to diagnosis. It remains to be seen whether the increase in testing will immediately lead to an increase in access to antiretroviral therapy (ART) services for infants.

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Year:  2008        PMID: 18511477     DOI: 10.1093/tropej/fmn036

Source DB:  PubMed          Journal:  J Trop Pediatr        ISSN: 0142-6338            Impact factor:   1.165


  22 in total

1.  Lessons learned from implementing the HIV infant tracking system (HITSystem): A web-based intervention to improve early infant diagnosis in Kenya.

Authors:  S Finocchario-Kessler; I Odera; V Okoth; C Bawcom; B Gautney; S Khamadi; K Clark; K Goggin
Journal:  Healthc (Amst)       Date:  2015-08-14

Review 2.  Point-of-care nucleic acid testing for infectious diseases.

Authors:  Angelika Niemz; Tanya M Ferguson; David S Boyle
Journal:  Trends Biotechnol       Date:  2011-03-04       Impact factor: 19.536

3.  Active tracking of rejected dried blood samples in a large program in Nigeria.

Authors:  Auchi Inalegwu; Sunny Phillips; Rawlings Datir; Christopher Chime; Petronilla Ozumba; Samuel Peters; Obinna Ogbanufe; Charles Mensah; Alash'Le Abimiku; Patrick Dakum; Nicaise Ndembi
Journal:  World J Virol       Date:  2016-05-12

4.  If you text them, they will come: using the HIV infant tracking system to improve early infant diagnosis quality and retention in Kenya.

Authors:  Sarah Finocchario-Kessler; Brad J Gautney; Samoel Khamadi; Vincent Okoth; Kathy Goggin; Jennifer K Spinler; Anne Mwangi; Davies Kimanga; Kristine F Clark; Helen D Olungae; Geoffrey A Preidis
Journal:  AIDS       Date:  2014-07       Impact factor: 4.177

5.  Assessment of Prevention of Mother-to-Child Transmission HIV Services in the Bantey Meanchey Province in Cambodia.

Authors:  Mealiny Sokun Sau; Maya Balamane; Mark Lurie; Joseph Harwell; Emily Welle; Chhivun Mean; Susan Cu-Uvin
Journal:  J Int Assoc Provid AIDS Care       Date:  2015-09-03

6.  The cost-effectiveness of repeat HIV testing during pregnancy in a resource-limited setting.

Authors:  Lena H Kim; Deborah L Cohan; Teresa N Sparks; Rachel A Pilliod; Emmanuel Arinaitwe; Aaron B Caughey
Journal:  J Acquir Immune Defic Syndr       Date:  2013-06-01       Impact factor: 3.731

7.  Early detection of HIV infection among Kenyan infants using a reverse transcriptase activity assay.

Authors:  Sumathi Sivapalasingam; Aabid Ahmed; Megan Mendillo; Robert Holzman; Fatuma Marshed; Musa Mwamzuka; Samuel Khamadi; Matilu Mwau; Maura Laverty; Fred Valentine
Journal:  Pediatr Infect Dis J       Date:  2012-07       Impact factor: 2.129

8.  Rapid detection of HIV-1 proviral DNA for early infant diagnosis using recombinase polymerase amplification.

Authors:  David S Boyle; Dara A Lehman; Lorraine Lillis; Dylan Peterson; Mitra Singhal; Niall Armes; Mathew Parker; Olaf Piepenburg; Julie Overbaugh
Journal:  MBio       Date:  2013-04-02       Impact factor: 7.867

9.  Introducing a multi-site program for early diagnosis of HIV infection among HIV-exposed infants in Tanzania.

Authors:  Harriet Nuwagaba-Biribonwoha; Bazghina Werq-Semo; Aziz Abdallah; Amy Cunningham; John G Gamaliel; Sevestine Mtunga; Victoria Nankabirwa; Isaya Malisa; Luis F Gonzalez; Charles Massambu; Denis Nash; Jessica Justman; Elaine J Abrams
Journal:  BMC Pediatr       Date:  2010-06-17       Impact factor: 2.125

Review 10.  Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions.

Authors:  Andrea L Ciaranello; Ji-Eun Park; Lynn Ramirez-Avila; Kenneth A Freedberg; Rochelle P Walensky; Valeriane Leroy
Journal:  BMC Med       Date:  2011-05-20       Impact factor: 8.775

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