Literature DB >> 1850550

Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product.

A R Nebreda1, D Martin-Zanca, D R Kaplan, L F Parada, E Santos.   

Abstract

The effect of nerve growth factor (NGF) was assessed in Xenopus oocytes expressing the human trk proto-oncogene product, p140prototrk. Oocytes injected with trk messenger RNA expressed polypeptides recognized by antibodies to the trk gene product. Exposure of these oocytes to nanomolar amounts of NGF resulted in specific surface binding of 125I-labeled NGF, tyrosine phosphorylation of p140prototrk, and meiotic maturation, as determined by germinal vesicle breakdown and maturation promoting factor (p34cdc2) kinase activation. Thus the trk proto-oncogene product can act as a receptor for NGF in a functionally productive manner.

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Year:  1991        PMID： 1850550     DOI： 10.1126/science.1850550

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

Review 1.  Identification of tyrosine kinase Trk as a nerve growth factor receptor.

Authors:  A H Ross
Journal:  Cell Regul       Date:  1991-09

2.  The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.

Authors:  R Klein; V Nanduri; S A Jing; F Lamballe; P Tapley; S Bryant; C Cordon-Cardo; K R Jones; L F Reichardt; M Barbacid
Journal:  Cell       Date:  1991-07-26       Impact factor: 41.582

3.  Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum.

Authors:  F Hallböök; L G Lundin; K Kullander
Journal:  J Neurosci       Date:  1998-11-01       Impact factor: 6.167

4.  Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands.

Authors:  S Maliartchouk; H U Saragovi
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

5.  Expression of functional trk protooncogene in human monocytes.

Authors:  P B Ehrhard; U Ganter; A Stalder; J Bauer; U Otten
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

6.  TrkA activation is sufficient to rescue axotomized cholinergic neurons.

Authors:  C A Lucidi-Phillipi; D O Clary; L F Reichardt; F H Gage
Journal:  Neuron       Date:  1996-03       Impact factor: 17.173

7.  Nerve growth factor signals via preexisting TrkA receptor oligomers.

Authors:  Paul S Mischel; Joy A Umbach; Sepehr Eskandari; Shane G Smith; Cameron B Gundersen; Guido A Zampighi
Journal:  Biophys J       Date:  2002-08       Impact factor: 4.033

8.  Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

Authors:  J L Herrmann; D G Menter; J Hamada; D Marchetti; M Nakajima; G L Nicolson
Journal:  Mol Biol Cell       Date:  1993-11       Impact factor: 4.138

9.  Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

Authors:  R C Miranda; F Sohrabji; C D Toran-Allerand
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

10.  Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins.

Authors:  D A Grueneberg; K J Simon; K Brennan; M Gilman
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272
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