Literature DB >> 18504523

Novel deprotection method of Fmoc group under neutral hydrogenation conditions.

Tomohiro Maegawa1, Yuta Fujiwara, Takashi Ikawa, Hideo Hisashi, Yasunari Monguchi, Hironao Sajiki.   

Abstract

Novel deprotection method of the Fmoc (9-flurorenylmethoxycarbonyl) protective group under Pd/C-catalyzed hydrogenation conditions at room temperature was developed. The addition of CH(3)CN accelerated the deprotection of the Fmoc group, and also the application of H(2) pressure (3 atm) shows notable rate enhancement.

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Year:  2008        PMID: 18504523     DOI: 10.1007/s00726-008-0109-7

Source DB:  PubMed          Journal:  Amino Acids        ISSN: 0939-4451            Impact factor:   3.520


  2 in total

1.  Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives.

Authors:  Tomislav Portada; Davor Margetić; Vjekoslav Štrukil
Journal:  Molecules       Date:  2018-11-30       Impact factor: 4.411

2.  Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder.

Authors:  Wenchao Li; Jingjian Liu; Minghua Fan; Zhongtang Li; Yin Chen; Guisen Zhang; Zhuo Huang; Liangren Zhang
Journal:  Molecules       Date:  2018-04-24       Impact factor: 4.411

  2 in total

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