OBJECTIVES: To determine whether serum levels of potential markers could detect insulin resistance (IR) in young women with polycystic ovary syndrome (PCOS). METHODS: Serum levels of fasting glucose, insulin, intact proinsulin, resistin, and adiponectin were measured in 50 women with PCOS and known homeostatic model assessment (HOMA)-IR values (>or=2 indicating IR). The women were all younger than 25 years. RESULTS: Of the 50 women, 49 had undetectable levels of resistin, 50 had intact proinsulin levels within the normal range, and 50 had adiponectin levels of 8.4+/-3.3 mg/L, just below the normal range. When groups were compared, however, the 26 women (52%) with IR (HOMA-IR values >or=2) had significantly higher intact proinsulin levels (3.2+/-2.0 pmol/L vs 1.8+/-1.0 pmol/L; P<0.005) and significantly lower adiponectin levels (7.2+/-2.9 mg/L vs 9.7+/-3.3 mg/L; P<0.01), than the 24 women (48%) without IR. CONCLUSION: Serum levels of intact proinsulin, resistin, or adiponectin were not detectors of IR in individual young women with PCOS.
OBJECTIVES: To determine whether serum levels of potential markers could detect insulin resistance (IR) in young women with polycystic ovary syndrome (PCOS). METHODS: Serum levels of fasting glucose, insulin, intact proinsulin, resistin, and adiponectin were measured in 50 women with PCOS and known homeostatic model assessment (HOMA)-IR values (>or=2 indicating IR). The women were all younger than 25 years. RESULTS: Of the 50 women, 49 had undetectable levels of resistin, 50 had intact proinsulin levels within the normal range, and 50 had adiponectin levels of 8.4+/-3.3 mg/L, just below the normal range. When groups were compared, however, the 26 women (52%) with IR (HOMA-IR values >or=2) had significantly higher intact proinsulin levels (3.2+/-2.0 pmol/L vs 1.8+/-1.0 pmol/L; P<0.005) and significantly lower adiponectin levels (7.2+/-2.9 mg/L vs 9.7+/-3.3 mg/L; P<0.01), than the 24 women (48%) without IR. CONCLUSION: Serum levels of intact proinsulin, resistin, or adiponectin were not detectors of IR in individual young women with PCOS.
Authors: Karine Brochu-Gaudreau; Charlotte Rehfeldt; Richard Blouin; V Bordignon; Bruce D Murphy; Marie-France Palin Journal: Endocrine Date: 2009-12-01 Impact factor: 3.633
Authors: Bianca L Share; Geraldine A Naughton; Philippe Obert; Jennifer K Peat; Elizabeth A Aumand; Justin G Kemp Journal: PLoS One Date: 2015-06-26 Impact factor: 3.240
Authors: Barbara Šenk; Katja Goričar; Nika Aleksandra Kravos; Mojca Jensterle Sever; Andrej Janež; Vita Dolžan Journal: Int J Endocrinol Date: 2018-07-17 Impact factor: 3.257