Literature DB >> 18503203

Sansanmycins B and C, new components of sansanmycins.

Yunying Xie1, Hongzhang Xu, Shuyi Si, Chenghang Sun, Ruxian Chen.   

Abstract

Two new antibiotics, sansanmycins B and C, were isolated from Streptomyces sp. SS. Their structures were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Sansanmycins B and C exhibited inhibitory activity against our test strain of Pseudomonas aeruginosa with MIC values of 8.0 and 16 microg/ml, respectively. Sansanmycin B also exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant Mycobacterium tuberculosis, with the MIC values ranging from 8.0 to 20 microg/ml.

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Year:  2008        PMID： 18503203     DOI： 10.1038/ja.2008.34

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

2.  Precursor-directed biosynthesis of new sansanmycin analogs bearing para-substituted-phenylalanines with high yields.

Authors:  Ningning Zhang; Li Liu; Guangzhi Shan; Qiang Cai; Xuan Lei; Bin Hong; Linzhuan Wu; Yunying Xie; Ruxian Chen
Journal:  J Antibiot (Tokyo)       Date:  2016-02-24       Impact factor: 2.649

3.  SsaA, a member of a novel class of transcriptional regulators, controls sansanmycin production in Streptomyces sp. strain SS through a feedback mechanism.

Authors:  Qinglian Li; Lifei Wang; Yunying Xie; Songmei Wang; Ruxian Chen; Bin Hong
Journal:  J Bacteriol       Date:  2013-03-08       Impact factor: 3.490

4.  Draft genome sequence of Streptomyces sp. strain SS, which produces a series of uridyl peptide antibiotic sansanmycins.

Authors:  Lifei Wang; Yunying Xie; Qinglian Li; Ning He; Entai Yao; Hongzhang Xu; Ying Yu; Ruxian Chen; Bin Hong
Journal:  J Bacteriol       Date:  2012-12       Impact factor: 3.490

Review 5.  Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

Authors:  M McErlean; X Liu; Z Cui; B Gust; S G Van Lanen
Journal:  Nat Prod Rep       Date:  2021-07-21       Impact factor: 15.111

6.  Improving the N-terminal diversity of sansanmycin through mutasynthesis.

Authors:  Yuanyuan Shi; Zhibo Jiang; Xuan Lei; Ningning Zhang; Qiang Cai; Qinglian Li; Lifei Wang; Shuyi Si; Yunying Xie; Bin Hong
Journal:  Microb Cell Fact       Date:  2016-05-06       Impact factor: 5.328

7.  Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.

Authors:  Anh T Tran; Emma E Watson; Venugopal Pujari; Trent Conroy; Luke J Dowman; Andrew M Giltrap; Angel Pang; Weng Ruh Wong; Roger G Linington; Sebabrata Mahapatra; Jessica Saunders; Susan A Charman; Nicholas P West; Timothy D H Bugg; Julie Tod; Christopher G Dowson; David I Roper; Dean C Crick; Warwick J Britton; Richard J Payne
Journal:  Nat Commun       Date:  2017-03-01       Impact factor: 14.919
  7 in total

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