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Literature DB >> 18503194

Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora.

Hans-Peter Fiedler¹, Christina Bruntner, Julia Riedlinger, Alan T Bull, Gjert Knutsen, Michael Goodfellow, Amanda Jones, Luis Maldonado, Wasu Pathom-aree, Winfried Beil, Kathrin Schneider, Simone Keller, Roderich D Sussmuth.

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Entities: Chemical Disease Species

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Year: 2008 PMID： 18503194 DOI： 10.1038/ja.2008.125

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

28 in total

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2. Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species.

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Journal: Appl Environ Microbiol Date: 2010-06-18 Impact factor: 4.792

3. Molecular networking as a dereplication strategy.

Authors: Jane Y Yang; Laura M Sanchez; Christopher M Rath; Xueting Liu; Paul D Boudreau; Nicole Bruns; Evgenia Glukhov; Anne Wodtke; Rafael de Felicio; Amanda Fenner; Weng Ruh Wong; Roger G Linington; Lixin Zhang; Hosana M Debonsi; William H Gerwick; Pieter C Dorrestein
Journal: J Nat Prod Date: 2013-09-11 Impact factor: 4.050

4. Metagenome sequencing of fingermillet-associated microbial consortia provides insights into structural and functional diversity of endophytes.

Authors: M K Prasannakumar; H B Mahesh; Radhika U Desai; Bharath Kunduru; Karthik S Narayan; Kalavati Teli; M E Puneeth; R C Rajadurai; Buella Parivallal; Gopal Venkatesh Babu
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5. Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.

Authors: Hanseong Roh; Gabriel C Uguru; Hyeok-Jin Ko; Sujin Kim; Byung-Yong Kim; Michael Goodfellow; Alan T Bull; Kyoung Heon Kim; Mervyn J Bibb; In-Geol Choi; James E M Stach
Journal: J Bacteriol Date: 2011-05-06 Impact factor: 3.490

6. First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp.

Authors: Thomas P Wyche; Yanpeng Hou; Doug Braun; Hannah C Cohen; May P Xiong; Tim S Bugni
Journal: J Org Chem Date: 2011-07-20 Impact factor: 4.354

7. Anti-methicillin Resistant Staphylococcus aureus Compound Isolation from Halophilic Bacillus amyloliquefaciens MHB1 and Determination of Its Mode of Action Using Electron Microscope and Flow Cytometry Analysis.

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