OBJECTIVE: To investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. METHODS: The monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05. RESULTS: The expressions of NGF and GDNF in the group B were significantly higher than those in the group A (P < 0.05). CONCLUSION: NGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.
OBJECTIVE: To investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. METHODS: The monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05. RESULTS: The expressions of NGF and GDNF in the group B were significantly higher than those in the group A (P < 0.05). CONCLUSION:NGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.
Authors: R C Armstrong; T J Aja; K D Hoang; S Gaur; X Bai; E S Alnemri; G Litwack; D S Karanewsky; L C Fritz; K J Tomaselli Journal: J Neurosci Date: 1997-01-15 Impact factor: 6.167
Authors: D W Nicholson; A Ali; N A Thornberry; J P Vaillancourt; C K Ding; M Gallant; Y Gareau; P R Griffin; M Labelle; Y A Lazebnik Journal: Nature Date: 1995-07-06 Impact factor: 49.962
Authors: Theodore J Price; Michael D Louria; Damaries Candelario-Soto; Gregory O Dussor; Nathanial A Jeske; Amol M Patwardhan; Anibal Diogenes; Amanda A Trott; Kenneth M Hargreaves; Christopher M Flores Journal: BMC Neurosci Date: 2005-01-24 Impact factor: 3.288