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Literature DB >> 1849230

Hexose metabolism in pancreatic islets: the glucose-6-phosphatase riddle.

Abstract

Glucose-6-phosphatase activity was measured in rat liver or pancreatic islet crude homogenates and microsomes. The data recorded in the liver were comparable to those reported in prior studies. However, in the islets, the hydrolysis of D-glucose 6-phosphate by disrupted microsomes represented, when expressed relative to the protein content, less than 2% of the value recorded in liver microsomes. Moreover, no phosphotransferase activity was detected in the islets. These findings impose reservation on both the presence of glucose-6-phosphatase in rat islets and its participation to stimulus-secretion coupling.

Entities: Chemical Disease Gene Species

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Year: 1991 PMID： 1849230 DOI： 10.1007/bf00238439

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

11 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Glucose-6-phosphatase activity in fed rat liver.

Authors: I D Waddell; A Burchell
Journal: Biochem J Date: 1990-03-01 Impact factor: 3.857

3. The microsomal glucose-6-phosphatase enzyme of pancreatic islets.

Authors: I D Waddell; A Burchell
Journal: Biochem J Date: 1988-10-15 Impact factor: 3.857

4. Underestimation of D-glucose phosphorylation as measured by 3H2O production from D-[2-3H]glucose.

Authors: W J Malaisse; M T Yilmaz; F Malaisse-Lagae; A Sener
Journal: Biochem Med Metab Biol Date: 1988-08

5. Latency and inhibitability by metabolites of glucose-6-phosphatase of permeable hepatocytes from fasted and fed rats.

Authors: R C Nordlie; R A Jorgenson
Journal: J Biol Chem Date: 1981-05-25 Impact factor: 5.157

6. Hexose metabolism in pancreatic islets. Inhibition of hexokinase.

Authors: M H Giroix; A Sener; D G Pipeleers; W J Malaisse
Journal: Biochem J Date: 1984-10-15 Impact factor: 3.857

7. The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets.

Authors: W J Malaisse; A C Boschero; S Kawazu; J C Hutton
Journal: Pflugers Arch Date: 1978-03-20 Impact factor: 3.657

8. Studies on the intracellular composition of livers from rats fed various aminoazo dyes; 3'-methyl-,2'-methyl-, and 2-methyl-4-dimethylaminoazobenzene,3-methyl-4-monomethylaminoazobenzene, and 4'-fluoro-4-dimethylaminoazobenzene.

Authors: J M PRICE; E C MILLER
Journal: Cancer Res Date: 1950-01 Impact factor: 12.701

Hexose metabolism in pancreatic islets: the glucose-6-phosphatase riddle.

1. Protein measurement with the Folin phenol reagent.

2. Glucose-6-phosphatase activity in fed rat liver.

3. The microsomal glucose-6-phosphatase enzyme of pancreatic islets.

4. Underestimation of D-glucose phosphorylation as measured by 3H2O production from D-[2-3H]glucose.

5. Latency and inhibitability by metabolites of glucose-6-phosphatase of permeable hepatocytes from fasted and fed rats.

6. Hexose metabolism in pancreatic islets. Inhibition of hexokinase.

7. The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets.

8. Studies on the intracellular composition of livers from rats fed various aminoazo dyes; 3'-methyl-,2'-methyl-, and 2-methyl-4-dimethylaminoazobenzene,3-methyl-4-monomethylaminoazobenzene, and 4'-fluoro-4-dimethylaminoazobenzene.

9. Cholinergic stimulation of ion fluxes in pancreatic islets.

10. Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse.

1. Time-dependent mechanisms in beta-cell glucose sensing.

2. Characterization of prenylcysteine methyltransferase in insulin-secreting cells.

3. Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.

4. Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets.