Literature DB >> 18490733

Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D.

Mathias Krockenberger1, Yvonne Dombrowski, Claudia Weidler, Monika Ossadnik, Arnd Hönig, Sebastian Häusler, Heike Voigt, Jürgen C Becker, Lin Leng, Alexander Steinle, Michael Weller, Richard Bucala, Johannes Dietl, Jörg Wischhusen.   

Abstract

The proinflammatory cytokine macrophage migration inhibitory factor (MIF) stimulates tumor cell proliferation, migration, and metastasis; promotes tumor angiogenesis; suppresses p53-mediated apoptosis; and inhibits antitumor immunity by largely unknown mechanisms. We here describe an overexpression of MIF in ovarian cancer that correlates with malignancy and the presence of ascites. Functionally, we find that MIF may contribute to the immune escape of ovarian carcinoma by transcriptionally down-regulating NKG2D in vitro and in vivo which impairs NK cell cytotoxicity toward tumor cells. Together with the additional tumorigenic properties of MIF, this finding provides a rationale for novel small-molecule inhibitors of MIF to be used for the treatment of MIF-secreting cancers.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18490733      PMCID： PMC3607742          DOI： 10.4049/jimmunol.180.11.7338

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  53 in total

1.  Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation.

Authors:  N M Valiante; M Rengaraju; G Trinchieri
Journal:  Cell Immunol       Date:  1992-11       Impact factor: 4.868

Review 2.  Paradoxical roles of the immune system during cancer development.

Authors:  Karin E de Visser; Alexandra Eichten; Lisa M Coussens
Journal:  Nat Rev Cancer       Date:  2006-01       Impact factor: 60.716

Review 3.  Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory diseases.

Authors:  Richard Bucala; Elias Lolis
Journal:  Drug News Perspect       Date:  2005-09

4.  Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response.

Authors:  Robert A Mitchell; Hong Liao; Jason Chesney; Gunter Fingerle-Rowson; John Baugh; John David; Richard Bucala
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-26       Impact factor: 11.205

5.  Targeting of CD44 eradicates human acute myeloid leukemic stem cells.

Authors:  Liqing Jin; Kristin J Hope; Qiongli Zhai; Florence Smadja-Joffe; John E Dick
Journal:  Nat Med       Date:  2006-09-24       Impact factor: 53.440

6.  Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.

Authors:  V Groh; R Rhinehart; J Randolph-Habecker; M S Topp; S R Riddell; T Spies
Journal:  Nat Immunol       Date:  2001-03       Impact factor: 25.606

7.  Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells.

Authors:  Jianqing Fan; Yongxiong Chen; Hiu Man Chan; Paul K H Tam; Yi Ren
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-28       Impact factor: 11.205

8.  Cutting edge: macrophage migration inhibitory factor is necessary for progression of experimental autoimmune encephalomyelitis.

Authors:  Nicole D Powell; Tracey L Papenfuss; Melanie A McClain; Ingrid E Gienapp; Todd M Shawler; Abhay R Satoskar; Caroline C Whitacre
Journal:  J Immunol       Date:  2005-11-01       Impact factor: 5.422

9.  Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

Authors:  Tyler J Curiel; George Coukos; Linhua Zou; Xavier Alvarez; Pui Cheng; Peter Mottram; Melina Evdemon-Hogan; Jose R Conejo-Garcia; Lin Zhang; Matthew Burow; Yun Zhu; Shuang Wei; Ilona Kryczek; Ben Daniel; Alan Gordon; Leann Myers; Andrew Lackner; Mary L Disis; Keith L Knutson; Lieping Chen; Weiping Zou
Journal:  Nat Med       Date:  2004-08-22       Impact factor: 53.440

10.  The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.

Authors:  G Fingerle-Rowson; O Petrenko; C N Metz; T G Forsthuber; R Mitchell; R Huss; U Moll; W Müller; R Bucala
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-23       Impact factor: 11.205
View more
  64 in total

Review 1.  Macrophage migration inhibitory factor (MIF): a promising biomarker.

Authors:  Gerrit Grieb; Melanie Merk; Jürgen Bernhagen; Richard Bucala
Journal:  Drug News Perspect       Date:  2010-05

2.  Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.

Authors:  Yuk Pheel Park; Seung-Chul Choi; Patricia Kiesler; Aleksandra Gil-Krzewska; Francisco Borrego; Jennifer Weck; Konrad Krzewski; John E Coligan
Journal:  Blood       Date:  2011-08-03       Impact factor: 22.113

Review 3.  Targeted immune therapy of ovarian cancer.

Authors:  Keith L Knutson; Lavakumar Karyampudi; Purushottam Lamichhane; Claudia Preston
Journal:  Cancer Metastasis Rev       Date:  2015-03       Impact factor: 9.264

Review 4.  Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes.

Authors:  Bruna Corradetti; Simone Pisano; Robert Steven Conlan; Mauro Ferrari
Journal:  J Pharmacol Exp Ther       Date:  2019-02-08       Impact factor: 4.030

5.  Effect of entinostat on NK cell-mediated cytotoxicity against osteosarcoma cells and osteosarcoma lung metastasis.

Authors:  Simin Kiany; Gangxiong Huang; Eugenie S Kleinerman
Journal:  Oncoimmunology       Date:  2017-07-11       Impact factor: 8.110

Review 6.  Oncogenic stress sensed by the immune system: role of natural killer cell receptors.

Authors:  David H Raulet; Nadia Guerra
Journal:  Nat Rev Immunol       Date:  2009-08       Impact factor: 53.106

7.  Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells.

Authors:  Robert A Eagle; Insiya Jafferji; Alexander D Barrow
Journal:  Curr Immunol Rev       Date:  2009-02

8.  MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells.

Authors:  Jennifer A A Gubbels; Mildred Felder; Sachi Horibata; Jennifer A Belisle; Arvinder Kapur; Helen Holden; Sarah Petrie; Martine Migneault; Claudine Rancourt; Joseph P Connor; Manish S Patankar
Journal:  Mol Cancer       Date:  2010-01-20       Impact factor: 27.401

9.  MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages.

Authors:  Lidia Prieto-Lafuente; William F Gregory; Judith E Allen; Rick M Maizels
Journal:  J Leukoc Biol       Date:  2009-01-29       Impact factor: 4.962

10.  Identification of macrophage migration inhibitory factor and human neutrophil peptides 1-3 as potential biomarkers for gastric cancer.

Authors:  Y Mohri; T Mohri; W Wei; Y-J Qi; A Martin; C Miki; M Kusunoki; D G Ward; P J Johnson
Journal:  Br J Cancer       Date:  2009-06-23       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.