Literature DB >> 16237048

Cutting edge: macrophage migration inhibitory factor is necessary for progression of experimental autoimmune encephalomyelitis.

Nicole D Powell1, Tracey L Papenfuss, Melanie A McClain, Ingrid E Gienapp, Todd M Shawler, Abhay R Satoskar, Caroline C Whitacre.   

Abstract

Macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of inflammatory and autoimmune diseases. The role of MIF in the progression of experimental autoimmune encephalomyelitis (EAE) was explored using MIF-/- mice. Wild-type mice showed a progressive disease course, whereas MIF-/- mice exhibited acute signs but no further progression of clinical disease. MIF-/- mice displayed markedly elevated corticosterone levels and significant decreases in the inflammatory cytokines TNF-alpha, IFN-gamma, IL-2, and IL-6 before, during, and after EAE onset. Taken together, these findings support that MIF is an important mediator of EAE progression through glucocorticoid antagonism and up-regulation of the inflammatory response.

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Year:  2005        PMID： 16237048     DOI： 10.4049/jimmunol.175.9.5611

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  21 in total

1.  HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis.

Authors:  Roberto Meza-Romero; Gil Benedek; Xiaolin Yu; Jeffery L Mooney; Rony Dahan; Nerri Duvshani; Richard Bucala; Halina Offner; Yoram Reiter; Gregory G Burrows; Arthur A Vandenbark
Journal:  J Immunol       Date:  2014-03-28       Impact factor: 5.422

2.  A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.

Authors:  Aaron P Kithcart; Gina M Cox; Thais Sielecki; Abigail Short; James Pruitt; Tracey Papenfuss; Todd Shawler; Ingrid Gienapp; Abhay R Satoskar; Caroline C Whitacre
Journal:  FASEB J       Date:  2010-07-12       Impact factor: 5.191

3.  A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.

Authors:  Arthur A Vandenbark; Roberto Meza-Romero; Gil Benedek; Shayne Andrew; Jianya Huan; Yuan K Chou; Abigail C Buenafe; Rony Dahan; Yoram Reiter; Jeffery L Mooney; Halina Offner; Gregory G Burrows
Journal:  J Autoimmun       Date:  2012-09-29       Impact factor: 7.094

4.  Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential.

Authors:  Joshua Bloom; Christine Metz; Saisha Nalawade; Julian Casabar; Kai Fan Cheng; Mingzhu He; Barbara Sherry; Thomas Coleman; Thomas Forsthuber; Yousef Al-Abed
Journal:  J Biol Chem       Date:  2016-10-28       Impact factor: 5.157

5.  MIF and D-DT are potential disease severity modifiers in male MS subjects.

Authors:  Gil Benedek; Roberto Meza-Romero; Kelley Jordan; Ying Zhang; Ha Nguyen; Gail Kent; Jia Li; Edwin Siu; Jenny Frazer; Marta Piecychna; Xin Du; Antoine Sreih; Lin Leng; Jack Wiedrick; Stacy J Caillier; Halina Offner; Jorge R Oksenberg; Vijayshree Yadav; Dennis Bourdette; Richard Bucala; Arthur A Vandenbark
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-18       Impact factor: 11.205

6.  Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking.

Authors:  Julia L Gregory; Pam Hall; Michelle Leech; Eric F Morand; Michael J Hickey
Journal:  Microcirculation       Date:  2009-11       Impact factor: 2.628

7.  Reduced arthritis in MIF deficient mice is associated with reduced T cell activation: down-regulation of ERK MAP kinase phosphorylation.

Authors:  L L Santos; A Dacumos; J Yamana; L Sharma; E F Morand
Journal:  Clin Exp Immunol       Date:  2008-03-12       Impact factor: 4.330

8.  Essential role for macrophage migration inhibitory factor in gastritis induced by Helicobacter pylori.

Authors:  Benny L W Wong; Sen-Lin Zhu; Xiao R Huang; Juan Ma; Harry H X Xia; Richard Bucala; Benjamin C Y Wong; Hui Yao Lan
Journal:  Am J Pathol       Date:  2009-03-12       Impact factor: 4.307

9.  Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D.

Authors:  Mathias Krockenberger; Yvonne Dombrowski; Claudia Weidler; Monika Ossadnik; Arnd Hönig; Sebastian Häusler; Heike Voigt; Jürgen C Becker; Lin Leng; Alexander Steinle; Michael Weller; Richard Bucala; Johannes Dietl; Jörg Wischhusen
Journal:  J Immunol       Date:  2008-06-01       Impact factor: 5.422

10.  Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection.

Authors:  Christian Østergaard; Thomas Benfield
Journal:  Crit Care       Date:  2009       Impact factor: 9.097
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