Literature DB >> 18485717

Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase.

Yusuke Hirasawa1, Eri Kato, Jun'ichi Kobayashi, Nobuo Kawahara, Yukihiro Goda, Motoo Shiro, Hiroshi Morita.   

Abstract

Three new Lycopodium alkaloids, lycoparins A-C (1-3), have been isolated from the club moss Lycopodium casuarinoides. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Lycoparins C (3) exhibited an inhibitory activity against acetylcholinesterase, while lycoparins A (1) and B (2) did not show activity.

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Year:  2008        PMID： 18485717     DOI： 10.1016/j.bmc.2008.04.044

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

Review 1.  Natural products as a source of Alzheimer's drug leads.

Authors:  Philip Williams; Analia Sorribas; Melanie-Jayne R Howes
Journal:  Nat Prod Rep       Date:  2010-11-12       Impact factor: 13.423

2.  Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy.

Authors:  Ana Paula Murray; María Belén Faraoni; María Julia Castro; Natalia Paola Alza; Valeria Cavallaro
Journal:  Curr Neuropharmacol       Date:  2013-07       Impact factor: 7.363

3.  Mining lycodine-type alkaloid biosynthetic genes and genetic markers from transcriptome of Lycopodiastrum casuarinoides.

Authors:  Gang Chen; Qiu-Mei Lin; Lin Zeng; Yi-Ping Zou
Journal:  Chin Herb Med       Date:  2020-03-27

Review 4.  Pyridine alkaloids with activity in the central nervous system.

Authors:  Simon X Lin; Maurice A Curtis; Jonathan Sperry
Journal:  Bioorg Med Chem       Date:  2020-10-16       Impact factor: 3.641
  4 in total

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