BACKGROUND: Our aim was to prospectively assess whether magnetic resonance (MR) diffusion-weighted (DW) imaging using high b values can predict better than b value of 1,000 s/mm(2) the histopathological grade of cerebral gliomas. METHODS: Fifty-four patients with histologically verified brain gliomas (35 high-grade and 19 low-grade gliomas) underwent MR DW imaging. Isotropic DW images and apparent diffusion coefficient (ADC) were obtained with b values of 1,000 and 3,000 s/mm(2). Each tumor was evaluated as being hyperintense, iso-intense or hypointense to normal, contralateral-hemisphere white matter. RESULTS: Most of the patients with high- and low-grade gliomas showed areas of increased signal intensity on their isotropic images, obtained with a b value of 1,000 s/mm(2). However, with a b value of 3,000 s/mm(2) the areas of increased signal intensity were seen in 97.1% of the high-grade gliomas, while 94.7% of the low-grade gliomas showed no area of increased signal intensity. The mean area under the ROC curve for ADC ratio, obtained with a b value of 3,000 s/mm(2), was significantly higher than that obtained with 1,000 s/mm(2) (.932 vs. .856, P= .04). CONCLUSION: High b value DW MR might be useful as a complementary tool in preoperative assessment of the histopathological grading of cerebral gliomas.
BACKGROUND: Our aim was to prospectively assess whether magnetic resonance (MR) diffusion-weighted (DW) imaging using high b values can predict better than b value of 1,000 s/mm(2) the histopathological grade of cerebral gliomas. METHODS: Fifty-four patients with histologically verified brain gliomas (35 high-grade and 19 low-grade gliomas) underwent MR DW imaging. Isotropic DW images and apparent diffusion coefficient (ADC) were obtained with b values of 1,000 and 3,000 s/mm(2). Each tumor was evaluated as being hyperintense, iso-intense or hypointense to normal, contralateral-hemisphere white matter. RESULTS: Most of the patients with high- and low-grade gliomas showed areas of increased signal intensity on their isotropic images, obtained with a b value of 1,000 s/mm(2). However, with a b value of 3,000 s/mm(2) the areas of increased signal intensity were seen in 97.1% of the high-grade gliomas, while 94.7% of the low-grade gliomas showed no area of increased signal intensity. The mean area under the ROC curve for ADC ratio, obtained with a b value of 3,000 s/mm(2), was significantly higher than that obtained with 1,000 s/mm(2) (.932 vs. .856, P= .04). CONCLUSION: High b value DW MR might be useful as a complementary tool in preoperative assessment of the histopathological grading of cerebral gliomas.
Authors: A Gupta; R J Young; A I Holodny; A B Lassman; S Karimi; S Sood; Z Zhang; Q Mo; P H Gutin Journal: AJNR Am J Neuroradiol Date: 2011-05-19 Impact factor: 3.825
Authors: Sarah Jost Fouke; Tammie Benzinger; Daniel Gibson; Timothy C Ryken; Steven N Kalkanis; Jeffrey J Olson Journal: J Neurooncol Date: 2015-11-03 Impact factor: 4.130