PURPOSE: To determine the neurological complications associated with sickle cell anaemia (SCA) in Nigerians and evaluate the relative frequencies. METHODOLOGY: Six-hundred-thirteen patients with SCA attending outpatient clinics of Lagos University Teaching Hospital and 616 control subjects were evaluated using a uniform structured questionnaire to determine the occurrence of neurological complications. The relative frequencies of neurological abnormalities in patients and controls were compared. RESULTS: Neurological abnormalities occurred in a significantly higher percentage of patients (76%) compared to controls (32.1%). Among children, these abnormalities included stroke, febrile seizures and headache. Among adolescents and adults, the abnormalities included paraplegia, epileptic seizures and localized sensory neuropathy. Headache occurred in a significantly higher percentage in children and adolescents compared to controls, but not in adults. CONCLUSIONS: We conclude that SCA is associated with neurological complications: stroke and febrile seizures in children, epileptic seizures, paraplegia and localized sensory neuropathy in adolescents and adults, headache in children and adolescents. Detailed studies of each of these complications would be required to provide further insight into their significance.
PURPOSE: To determine the neurological complications associated with sickle cell anaemia (SCA) in Nigerians and evaluate the relative frequencies. METHODOLOGY: Six-hundred-thirteen patients with SCA attending outpatient clinics of Lagos University Teaching Hospital and 616 control subjects were evaluated using a uniform structured questionnaire to determine the occurrence of neurological complications. The relative frequencies of neurological abnormalities in patients and controls were compared. RESULTS:Neurological abnormalities occurred in a significantly higher percentage of patients (76%) compared to controls (32.1%). Among children, these abnormalities included stroke, febrile seizures and headache. Among adolescents and adults, the abnormalities included paraplegia, epileptic seizures and localized sensory neuropathy. Headache occurred in a significantly higher percentage in children and adolescents compared to controls, but not in adults. CONCLUSIONS: We conclude that SCA is associated with neurological complications: stroke and febrile seizures in children, epileptic seizures, paraplegia and localized sensory neuropathy in adolescents and adults, headache in children and adolescents. Detailed studies of each of these complications would be required to provide further insight into their significance.
Authors: Michael M Dowling; Michael J Noetzel; Mark J Rodeghier; Charles T Quinn; Deborah G Hirtz; Rebecca N Ichord; Janet L Kwiatkowski; E Steven Roach; Fenella J Kirkham; James F Casella; Michael R DeBaun Journal: J Pediatr Date: 2014-02-13 Impact factor: 4.406
Authors: Lianna J Marks; Deogratias Munube; Philip Kasirye; Ezekiel Mupere; Zhezhen Jin; Philip LaRussa; Richard Idro; Nancy S Green Journal: Glob Pediatr Health Date: 2018-05-14
Authors: Iman M Talaat; Naglaa M Kamal; Ebtessam H K El Melegy; Hamed A Alghamdi; Mohammed F Aljabri; Enas A A Abdallah; Mohammed Sarar; Mohamed A Alshahrani Journal: Ann Med Surg (Lond) Date: 2015-11-10