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Literature DB >> 22077524

The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease.

John J Strouse¹, Sophie Lanzkron, Victor Urrutia.

Abstract

Stroke is a frequent and severe complication in adults with sickle cell disease. Ischemic stroke often causes physical and cognitive disability, while hemorrhagic stroke has a high mortality rate. As more children survive, the number of strokes in adults is increasing, yet stroke remains poorly understood. We review the epidemiology of ischemic and hemorrhagic stroke in adults with sickle cell disease and outline a practical approach to the evaluation of stroke including both sickle cell disease specific and general risk factors. We discuss the acute treatment and secondary prevention of stroke in this population based on the evidence in children with sickle cell disease and the general population, in addition to the limited studies in adults with sickle cell disease.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 22077524 PMCID： PMC3267235 DOI： 10.1586/ehm.11.61

Source DB: PubMed Journal: Expert Rev Hematol ISSN： 1747-4094 Impact factor: 2.929

75 in total

1. Homocysteine in sickle cell disease: relationship to stroke.

Authors: P E Houston; S Rana; S Sekhsaria; E Perlin; K S Kim; O L Castro
Journal: Am J Med Date: 1997-09 Impact factor: 4.965

2. Complications of sickle cell disease: intracranial aneurysms and their treatment.

Authors: N S McConachie; T Jaspan
Journal: Clin Radiol Date: 1998-05 Impact factor: 2.350

3. Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia.

Authors: C H Pegelow; L Colangelo; M Steinberg; E C Wright; J Smith; G Phillips; E Vichinsky
Journal: Am J Med Date: 1997-02 Impact factor: 4.965

4. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH): a phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload.

Authors: Russell E Ware; William H Schultz; Nancy Yovetich; Nicole A Mortier; Ofelia Alvarez; Lee Hilliard; Rathi V Iyer; Scott T Miller; Zora R Rogers; J Paul Scott; Myron Waclawiw; Ronald W Helms
Journal: Pediatr Blood Cancer Date: 2011-08-08 Impact factor: 3.167

5. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial.

Authors: A David Mendelow; Barbara A Gregson; Helen M Fernandes; Gordon D Murray; Graham M Teasdale; D Terence Hope; Abbas Karimi; M Donald M Shaw; David H Barer
Journal: Lancet Date: 2005 Jan 29-Feb 4 Impact factor: 79.321

6. Discontinuation of long-term transfusion therapy in patients with sickle cell disease and stroke.

Authors: S Rana; P E Houston; N Surana; E I Shalaby-Rana; O L Castro
Journal: J Pediatr Date: 1997-11 Impact factor: 4.406

7. Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler.

Authors: R J Adams; V C McKie; E M Carl; F T Nichols; R Perry; K Brock; K McKie; R Figueroa; M Litaker; S Weiner; D Brambilla
Journal: Ann Neurol Date: 1997-11 Impact factor: 10.422

8. Stroke recurrence in children with sickle cell disease treated with hydroxyurea following first clinical stroke.

Authors: Susanna Bortolusso Ali; Michelle Moosang; Lesley King; Jennifer Knight-Madden; Marvin Reid
Journal: Am J Hematol Date: 2011-09-02 Impact factor: 10.047

9. Stroke in children in Yaounde, Cameroon.

Authors: M T Obama; L Dongmo; C Nkemayim; J Mbede; P Hagbe
Journal: Indian Pediatr Date: 1994-07 Impact factor: 1.411

10. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.

Authors: R J Adams; V C McKie; L Hsu; B Files; E Vichinsky; C Pegelow; M Abboud; D Gallagher; A Kutlar; F T Nichols; D R Bonds; D Brambilla
Journal: N Engl J Med Date: 1998-07-02 Impact factor: 91.245

16 in total

1. Thrombolytic therapy for the treatment of acute ischaemic stroke in adults with homozygous sickle cell disease.

Authors: Loubna Majhadi; David Calvet; Charlotte Rosso; Pablo Bartolucci
Journal: BMJ Case Rep Date: 2017-07-28

2. Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease.

Authors: Andrew Srisuwananukorn; Rasha Raslan; Xu Zhang; Binal N Shah; Jin Han; Michel Gowhari; Robert E Molokie; Victor R Gordeuk; Santosh L Saraf
Journal: Blood Adv Date: 2020-05-12

Review 3. Chronic organ failure in adult sickle cell disease.

Authors: Elliott Vichinsky
Journal: Hematology Am Soc Hematol Educ Program Date: 2017-12-08

4. High incidence of venous thromboembolism recurrence in patients with sickle cell disease.

Authors: Ann Brunson; Theresa Keegan; Anjlee Mahajan; Richard White; Ted Wun
Journal: Am J Hematol Date: 2019-06-12 Impact factor: 10.047

5. Sickle cell trait and incident ischemic stroke in the Atherosclerosis Risk in Communities study.

Authors: Melissa C Caughey; Laura R Loehr; Nigel S Key; Vimal K Derebail; Rebecca F Gottesman; Abhijit V Kshirsagar; Megan L Grove; Gerardo Heiss
Journal: Stroke Date: 2014-08-19 Impact factor: 7.914

6. Differential cerebral hemometabolic responses to blood transfusions in adults and children with sickle cell anemia.

Authors: Meher R Juttukonda; Chelsea A Lee; Niral J Patel; Larry T Davis; Spencer L Waddle; Melissa C Gindville; Sumit Pruthi; Adetola A Kassim; Michael R DeBaun; Manus J Donahue; Lori C Jordan
Journal: J Magn Reson Imaging Date: 2018-10-15 Impact factor: 4.813