BACKGROUND: Early studies of incomplete pregnancy and development of breast cancer suggested that induced abortion might increase risk. Several large prospective studies, which eliminate recall bias, did not detect associations, but this relationship continues to be debated. STUDY DESIGN: To further inform this important question, we examined invasive breast cancer as it relates to incomplete pregnancy, including total number of induced abortions, age at first induced abortion and total number of miscarriages among women participating in the ongoing California Teachers Study (CTS) cohort. Incomplete pregnancy was self-reported on the CTS baseline questionnaire in 1995-1996. Incident breast cancers were ascertained in 3324 women through 2004 via linkage with the California Cancer Registry. RESULTS: Using Cox multivariable regression, we found no statistically significant association between any measure of incomplete pregnancy and breast cancer risk among nulliparous or parous women. CONCLUSION: These results provide strong evidence that there is no relationship between incomplete pregnancy and breast cancer risk.
BACKGROUND: Early studies of incomplete pregnancy and development of breast cancer suggested that induced abortion might increase risk. Several large prospective studies, which eliminate recall bias, did not detect associations, but this relationship continues to be debated. STUDY DESIGN: To further inform this important question, we examined invasive breast cancer as it relates to incomplete pregnancy, including total number of induced abortions, age at first induced abortion and total number of miscarriages among women participating in the ongoing California Teachers Study (CTS) cohort. Incomplete pregnancy was self-reported on the CTS baseline questionnaire in 1995-1996. Incident breast cancers were ascertained in 3324 women through 2004 via linkage with the California Cancer Registry. RESULTS: Using Cox multivariable regression, we found no statistically significant association between any measure of incomplete pregnancy and breast cancer risk among nulliparous or parous women. CONCLUSION: These results provide strong evidence that there is no relationship between incomplete pregnancy and breast cancer risk.
Authors: Leslie Bernstein; Mark Allen; Hoda Anton-Culver; Dennis Deapen; Pamela L Horn-Ross; David Peel; Richard Pinder; Peggy Reynolds; Jane Sullivan-Halley; Dee West; William Wright; Al Ziogas; Ronald K Ross Journal: Cancer Causes Control Date: 2002-09 Impact factor: 2.506
Authors: Gillian K Reeves; Sau-Wan Kan; Tim Key; Anne Tjønneland; Anja Olsen; Kim Overvad; Petra H Peeters; Françoise Clavel-Chapelon; Xavier Paoletti; Franco Berrino; Vittorio Krogh; Domenico Palli; Rosario Tumino; Salvatore Panico; Paulo Vineis; Carlos A Gonzalez; Eva Ardanaz; Carmen Martinez; Pilar Amiano; José R Quiros; Maria R Tormo; Kay-Tee Khaw; Antonia Trichopoulou; Theodora Psaltopoulou; Victoria Kalapothaki; Gabriele Nagel; Jenny Chang-Claude; Heiner Boeing; Petra H Lahmann; Elisabet Wirfält; Rudolf Kaaks; Elio Riboli Journal: Int J Cancer Date: 2006-10-01 Impact factor: 7.396
Authors: Huiyan Ma; Katherine D Henderson; Jane Sullivan-Halley; Lei Duan; Sarah F Marshall; Giske Ursin; Pamela L Horn-Ross; Joan Largent; Dennis M Deapen; James V Lacey; Leslie Bernstein Journal: Breast Cancer Res Date: 2010-06-18 Impact factor: 6.466
Authors: Maggie Kirkman; Carmel Apicella; Jillian Graham; Martha Hickey; John L Hopper; Louise Keogh; Ingrid Winship; Jane Fisher Journal: BMC Womens Health Date: 2017-04-05 Impact factor: 2.809
Authors: Elham Manouchehri; Ali Taghipour; Vahid Ghavami; Fatemeh Homaei Shandiz; Abbas Ebadi; Robab Latifnejad Roudsari Journal: Int J Prev Med Date: 2022-02-23
Authors: Mohammad Esmaeil Akbari; Soheila Sayad; Saed Sayad; Maryam Khayamzadeh; Leila Shojaee; Zeynab Shormeji; Mojtaba Amiri Journal: Int J Breast Cancer Date: 2017-11-01