Literature DB >> 1847625

Frequency and amplitude enhancement of calcium transients by cyclic AMP in hepatocytes.

C Schöfl1, A Sanchez-Bueno, G Brabant, P H Cobbold, K S Cuthbertson.   

Abstract

Interactions between signalling pathways such as the cyclic AMP and the Ca2+/phosphatidylinositol pathway may occur and be of major relevance in the regulation of cell function. We demonstrate here that cyclic-AMP-dependent mechanisms cause a marked increase in frequency and peak free Ca2+ of alpha 1-receptor-induced Ca2+ transients in single hepatocytes and lower the threshold for alpha 1-receptor agonists. Adrenaline at low physiological concentrations generates alpha 1-receptor-induced Ca2+ transients, which requires activation of the beta 2-receptor signalling pathway. We conclude that an interaction between the alpha 1-receptor signalling pathway and cyclic-AMP-dependent mechanisms activated by beta 2-receptor occupation is crucial to elicit a complete adrenergic response to adrenaline at physiological concentrations in rat hepatocytes.

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Year:  1991        PMID： 1847625      PMCID： PMC1149834          DOI： 10.1042/bj2730799

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

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Journal:  Nature       Date:  1989-11-02       Impact factor: 49.962

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Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857

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Journal:  J Biol Chem       Date:  1983-07-25       Impact factor: 5.157

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Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

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Journal:  J Clin Invest       Date:  1980-07       Impact factor: 14.808
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  7 in total

1.  Different modulatory effects of elevated cyclic AMP on cytosolic Ca2+ spikes induced by phenylephrine or vasopressin in single rat hepatocytes.

Authors:  A Sanchez-Bueno; I Marrero; P H Cobbold
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

2.  Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca2+ mobilization in permeabilized hepatocytes.

Authors:  G Hajnóczky; E Gao; T Nomura; J B Hoek; A P Thomas
Journal:  Biochem J       Date:  1993-07-15       Impact factor: 3.857

3.  Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers. The synergism between the alpha 1-adrenergic response, glucagon and cyclic AMP, and their antagonism by insulin and diacylglycerol manifest themselves in the control of the cytosolic-[Ca2+] oscillations.

Authors:  R Somogyi; M Zhao; J W Stucki
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

Review 4.  Calcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists.

Authors:  F L Bygrave; A Benedetti
Journal:  Biochem J       Date:  1993-11-15       Impact factor: 3.857

5.  Elevated intracellular cyclic AMP exerts different modulatory effects on cytosolic free Ca2+ oscillations induced by ADP and ATP in single rat hepatocytes.

Authors:  A K Green; P H Cobbold; C J Dixon
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

6.  Biphasic short-circuit current response to noradrenaline mediated by Ca2+ and cAMP in cultured rat epididymal epithelium.

Authors:  A Y Leung; P Y Wong
Journal:  Pflugers Arch       Date:  1994-03       Impact factor: 3.657

7.  Cytosolic free Ca2+ oscillations induced by diadenosine 5',5"'-P1,P3-triphosphate and diadenosine 5',5"'-P1,P4-tetraphosphate in single rat hepatocytes are indistinguishable from those induced by ADP and ATP respectively.

Authors:  A K Green; P H Cobbold; C J Dixon
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857
  7 in total

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